Development of the corticospinal tract in the mouse spinal cord: a quantitative ultrastructural analysis

Brain Research
Jung-Yu C HsuXiao-Ming Xu

Abstract

The growth of corticospinal tract (CST) axons was studied quantitatively at the 7th cervical (C7) and the 4th lumbar (L4) spinal segments in the balb/cByJ mice at the ages of postnatal day (P) 0, 2, 4, 6, 8, 10, 14, and 28. The cross-sectional area of the CST increased progressively with time. Unmyelinated axons, the most prominent CST element during early development, reached maximum at C7 and L4 on P14. Two phases of increase in the number of unmyelinated axons were observed at C7, while only one surge of axonal outgrowth was found at the L4 level. Pro-myelinated axons, defined as axons surrounded by only one layer of oligodendrocytic process, were first seen at P2 and P4 in the C7 and the L4 level, respectively, followed by a dramatic increase in the number of myelinated axons from P14 onwards at both spinal levels. Myelination of the CST axons occurred topographically in a dorsal-to-ventral pattern. The number of growth cones increased rapidly at the C7 level to reach its maximum at P4, while those at L4 increased steadily to the peak at P10. Growth cones with synapse-like junctions were occasionally observed in the growing CST. Degenerating axons and growth cones partly accounted for the massive axon loss at both spinal se...Continue Reading

References

Sep 15, 1977·The Journal of Comparative Neurology·J M Donatelle
May 23, 1975·Brain Research·J R McClung, A J Castro
Nov 20, 1992·Brain Research. Developmental Brain Research·P H Harrison, M Porter
Jun 1, 1990·Brain Research. Developmental Brain Research·T G Gorgels
Dec 15, 1989·The Journal of Comparative Neurology·J T PattersonR E Coggeshall
Nov 1, 1988·The Journal of Physiology·D M Armstrong
Oct 1, 1988·The Journal of Comparative Neurology·P Berbel, G M Innocenti
Jan 1, 1988·Brain Research·D J Schreyer, E G Jones
Jan 1, 1987·Experimental Brain Research·M W Miller
Apr 1, 1986·The Journal of Comparative Neurology·R W WilliamsL M Chalupa
Aug 8, 1985·The Journal of Comparative Neurology·B B Stanfield, D D O'Leary
Jan 1, 1985·Anatomy and Embryology·E J de KortR Nieuwenhuys
Sep 1, 1972·The Journal of Comparative Neurology·S E Kornguth, G Scott
Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Nov 1, 1968·The Journal of Comparative Neurology·T Samorajski, R L Friede
Sep 21, 1984·Science·W M CowanB B Stanfield
Feb 10, 1982·The Journal of Comparative Neurology·T Reh, K Kalil
Jul 20, 1981·The Journal of Comparative Neurology·T Reh, K Kalil
May 13, 1994·Brain Research. Developmental Brain Research·E A JoostenW H Gispen
May 5, 1997·The Journal of Comparative Neurology·K A ColemanJ Mitrofanis
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·C AbbadieA I Basbaum

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Citations

Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ronaldo M IchiyamaLeif A Havton
Jun 1, 2008·Biologics : Targets & Therapy·Masaki Ueno, Toshihide Yamashita
Jul 6, 2014·Experimental Neurology·Alexander DrobyshevskySidhartha Tan
Feb 6, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kathren L Fink, William B J Cafferty
Apr 2, 2008·Progress in Neurobiology·A J Canty, M Murphy
Mar 21, 2009·Journal of Neuroscience Research·Miranda W Richter, A Jane Roskams
Mar 29, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gulgun SengulCharles Watson
Jan 31, 2012·Developmental Neuroscience·Akira YoshikawaKengo Funakoshi
Jul 19, 2011·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Eileen Burgin
Oct 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Ying WuRobert R Edelman
Sep 30, 2017·Neurology. Neuroimmunology and Neuroinflammation·Marc PawlitzkiStefanie Schreiber
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Seth A SmithGreg J Stanisz
Feb 2, 2013·AJNR. American Journal of Neuroradiology·J P Seo, S H Jang
Aug 15, 2019·Journal of Neurophysiology·Clarissa F CavarsanKatharina A Quinlan
May 17, 2019·Neural Plasticity·Mariangela GennaroTommaso Pizzorusso

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