PMID: 6409152Aug 1, 1983Paper

Development of the cytosolic defence system against microsomal lipid peroxidation in rat liver

Biochimica Et Biophysica Acta
S FairhurstA A Horton

Abstract

Ascorbate-induced lipid peroxidation in rat liver microsomes reaches the adult level in 2-3 days. NADPH-induced peroxidation develops more gradually, in parallel with the activity of NADPH-cytochrome P-450 reductase, attaining adult levels by 10-12 days. The glutathione-dependent cytosolic enzyme activity which inhibits peroxidation is inhibited by bromosulphophthalein. The development of this system lags behind the development of microsomal lipid peroxidation between the ages of 2 and 20 days, allowing peroxidation to proceed.

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Citations

May 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·V D AntonenkovA M Vikhert
Apr 1, 1987·Biulleten' eksperimental'noĭ biologii i meditsiny·L F PanchenkoV D Antonenkov
Nov 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·V D Antonenkov, L F Panchenko
Jan 1, 1985·Bulletin of Environmental Contamination and Toxicology·S NarayanU K Misra
Jan 1, 1987·Critical Reviews in Toxicology·A A Horton, S Fairhurst

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