PMID: 8959040Oct 31, 1996Paper

Development of the eye after gestational exposure to cocaine. Vascular disruption in the retina of rats and humans

Annals of the New York Academy of Sciences
A Silva-Araújo, M A Tavares

Abstract

Clinical and basic research in the area of drugs of abuse are of utmost importance since they provide the necessary background for health programs in one of the main problems of contemporary society. The available data in this field demonstrate that acute, subacute and/or chronic abuse of illicit drugs, e.g., cocaine, alters the neurochemistry and functioning of the neural circuitries. Although recent works demonstrated that the visual system is lesioned after exposure to cocaine during the active periods of development, no studies have provided detailed information on the effects of these substances on the development of this sensory system. The present paper will report: 1) the vulnerability of the developing visual system to gestational exposure to cocaine; 2) the effects of cocaine in the visual system during the more active periods of development in humans and, as far as possible, the establishment of homologies with animal models where exposure is made in corresponding periods of human gestation, and 3) the characterization of the vascular disruption caused by ischemic/hypoxic mechanisms. The clinical study focused the ophthalmologic evaluation of newborns exposed in utero to illicit drugs. Newborns exposed to cocaine in ...Continue Reading

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Citations

Feb 21, 2009·Eye·A Tandon, A Mulvihill
Jul 21, 1998·Annals of the New York Academy of Sciences·J Gomes-Da-SilvaM A Tavares
Mar 23, 2011·Journal of Pediatric Ophthalmology and Strabismus·Manish GuptaNick D George
Nov 13, 2013·Current Eye Research·Maria V Sánchez-VillarejoMaría Miranda
Aug 9, 2007·Neurotoxicology and Teratology·George H TrksakDenise Jackson
May 10, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Pedro MeloMaria Amélia Tavares
Nov 16, 2006·Annals of the New York Academy of Sciences·Lorena G RodriguesMaria Amélia Tavares
May 1, 1998·Annals of the New York Academy of Sciences·J Gomes-DA-SilvaM A Tavares

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