Development of the larval lymphatic system in zebrafish

Development
Hyun Min JungBrant M Weinstein

Abstract

The lymphatic vascular system is a hierarchically organized complex network essential for tissue fluid homeostasis, immune trafficking and absorption of dietary fats in the human body. Despite its importance, the assembly of the lymphatic network is still not fully understood. The zebrafish is a powerful model organism that enables study of lymphatic vessel development using high-resolution imaging and sophisticated genetic and experimental manipulation. Although several studies have described early lymphatic development in the fish, lymphatic development at later stages has not been completely elucidated. In this study, we generated a new Tg(mrc1a:egfp)y251 transgenic zebrafish that uses a mannose receptor, C type 1 (mrc1a) promoter to drive strong EGFP expression in lymphatic vessels at all stages of development and in adult zebrafish. We used this line to describe the assembly of the major vessels of the trunk lymphatic vascular network, including the later-developing collateral cardinal, spinal, superficial lateral and superficial intersegmental lymphatics. Our results show that major trunk lymphatic vessels are conserved in the zebrafish, and provide a thorough and complete description of trunk lymphatic vessel assembly.

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Citations

Feb 14, 2018·Current Opinion in Hematology·Ryota L Matsuoka, Didier Y R Stainier
May 17, 2018·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Dec 25, 2019·Cellular Microbiology·Erika M FloresAnne Marie Krachler
Apr 12, 2017·ELife·Marina Venero GalanternikBrant M Weinstein
Sep 4, 2019·ELife·Hyun Min JungBrant M Weinstein
Aug 2, 2019·Nature Communications·James H ThiererSteven A Farber
Mar 21, 2019·Biology Open·Kingsley Chukwunonso UgwuagboMousumi Majumder
Jun 14, 2019·Frontiers in Cell and Developmental Biology·Massimo M SantoroBrant M Weinstein
Nov 3, 2020·Circulation Research·Daniel CastranovaBrant M Weinstein
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Aryan KavehMartin A Denvir
Jan 16, 2021·Angiogenesis·Leah J Greenspan, Brant M Weinstein
Dec 29, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maxence FrétaudChristelle Langevin
Feb 5, 2021·Frontiers in Cell and Developmental Biology·M Fernanda Palominos, Kathleen E Whitlock
Dec 6, 2020·Communications Biology·Amber N StratmanBrant M Weinstein
Mar 7, 2021·Journal of Cardiovascular Development and Disease·Xidi FengMichael R M Harrison
Apr 8, 2021·Angiogenesis·Daniyal J JafreeChristiana Ruhrberg

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