Development of the lung liquid reabsorptive mechanism in fetal sheep: synergism of triiodothyronine and hydrocortisone

The Journal of Physiology
P M BarkerL B Strang

Abstract

1. Thyroidectomy was performed on twelve fetal sheep between 111 and 115 days gestation. Measurement of fetal lung liquid secretion and absorption rates (Jv) were made at rest and during short (45 min) and long (5 h) infusions of adrenaline (0.5 micrograms/min) in a total of thirty-seven experiments, some in the absence of triiodothyronine (T3) and hydrocortisone and some at set times after the administration of the two hormones. 2. T3 was given either as an I.V. infusion (60 micrograms/24 h) or as a bolus of 30 micrograms; hydrocortisone was given as an infusion of 10 mg/24 h. Both hormones were administered together. 3. Before T3 and hydrocortisone were given short infusions of adrenaline had no effect on Jv but 4 h after exposure to the hormones secretion rate was reduced to near zero (Jv = -0.5 +/- 1.6 ml/h, n = 4) by adrenaline; after 24 h of hormone exposure, absorption of fetal lung liquid was produced by adrenaline (Jv = -3.6 +/- 2.2 ml/h, n = 4) which was even greater after 72 h, (Jv = -11.2 +/- 2.2 ml/h, n = 4). 4. During long infusions of adrenaline when T3 and hydrocortisone were given at the start of the experiment, an effect on lung liquid secretion was evident at 2 h and absorption was produced at 4 h (Jv = -4.2 ...Continue Reading

Citations

May 24, 2003·Biochemical and Biophysical Research Communications·Kerry RichardStuart M Wilson
Mar 1, 1996·Respiration Physiology·K E WilletP D Sly
Feb 16, 2006·Histochemistry and Cell Biology·Christopher A D'AngelisBruce A Holm
Nov 17, 2007·Respiratory Physiology & Neurobiology·S M WilsonD V Walters
Aug 5, 2008·Acta Paediatrica·Richard Olver, Dafydd Walters
Mar 21, 1998·American Journal of Obstetrics and Gynecology·P J BergerA M Walker
Oct 8, 2014·Seminars in Cell & Developmental Biology·Stephen C LandDavid Walker
Nov 3, 2005·Paediatric Respiratory Reviews·S Kotecha
Feb 24, 2004·Annual Review of Physiology·Richard E OlverStuart M Wilson
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·S B Hooper, R Harding
Apr 12, 2003·Critical Care Medicine·Hans G Folkesson, Michael A Matthay
Aug 17, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Paul J Kemp, Kwang-Jin Kim
Mar 22, 2014·The Journal of Endocrinology·A J Forhead, A L Fowden
May 1, 1994·British Journal of Obstetrics and Gynaecology·N Modi
Sep 5, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianxun LeiDavid H Ingbar
Jul 17, 1998·Annals of Medicine·O M Pitkänen, H M O'Brodovich
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·Maneesh BhargavaDavid H Ingbar
Nov 1, 1992·Basic Research in Cardiology·R D Stith, Y S Reddy
Aug 1, 1993·American Journal of Respiratory Cell and Molecular Biology·G R Cott, A K Rao
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R D Bland
May 13, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianxun LeiDavid H Ingbar
Sep 18, 2002·Journal of Applied Physiology·Pierre M Barker, Richard E Olver
May 8, 1998·The Proceedings of the Nutrition Society·A L FowdenA J Forhead
Oct 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hans G FolkessonJoseph A Kitterman
May 12, 1998·The American Journal of Physiology·S MukhopadhyayP J Kemp
Feb 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hans G FolkessonJoseph A Kitterman
Nov 20, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·N VoilleyP Barbry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.