Development of the Mechanisms Governing Midbrain Multisensory Integration

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Cristiano CuppiniBenjamin A Rowland

Abstract

The ability to integrate information across multiple senses enhances the brain's ability to detect, localize, and identify external events. This process has been well documented in single neurons in the superior colliculus (SC), which synthesize concordant combinations of visual, auditory, and/or somatosensory signals to enhance the vigor of their responses. This increases the physiological salience of crossmodal events and, in turn, the speed and accuracy of SC-mediated behavioral responses to them. However, this capability is not an innate feature of the circuit and only develops postnatally after the animal acquires sufficient experience with covariant crossmodal events to form links between their modality-specific components. Of critical importance in this process are tectopetal influences from association cortex. Recent findings suggest that, despite its intuitive appeal, a simple generic associative rule cannot explain how this circuit develops its ability to integrate those crossmodal inputs to produce enhanced multisensory responses. The present neurocomputational model explains how this development can be understood as a transition from a default state in which crossmodal SC inputs interact competitively to one in whic...Continue Reading

Citations

Dec 5, 2019·Cerebral Cortex·Alexander S DakosBenjamin A Rowland
Nov 8, 2018·Scientific Reports·Saba GharaeiSamuel G Solomon
Oct 20, 2018·Frontiers in Integrative Neuroscience·Olga I Dadalko, Brittany G Travers
May 20, 2020·Frontiers in Integrative Neuroscience·Zhengyang WangBenjamin A Rowland

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