PMID: 11905202Jun 1, 1968Paper

Development of the metanephric kidney. Protein and nucleic acid synthesis

The Journal of Cell Biology
G C Priestley, R A Malt

Abstract

The metanephric kidney was studied in fetal and older mice beginning at 16 days after mating of the parents. Polyribosomes from fetal kidneys labeled in vitro with 14C-labeled amino acids had 10-20 times more acid-precipitable radioactivity associated with them than polysomes from adult kidneys similarly labeled. Between 3 and 6 days after birth the rate incorporation of labeled amino acids by polyribosomes from neonatal kidneys declined sharply to only twice the value found for adult kidneys. There was no change in the shape of the polyribosome profile with increasing age, but before birth few, if any, ribosomes were bound to membranes compared with 20% 2 days after birth and between 20 and 30% in the adult. Total protein represented less than 10% of the wet weight in the fetal kidney but increased to 17% of the wet weight in the adult kidney. There was a steady decline in the concentration of RNA and DNA with respect to dry weight throughout kidney development. DNA concentration declined more rapidly than RNA concentration, so that the milligram to milligram ratio of RNA to DNA increased. In males the RNA/DNA ratio was stable at 1.3 at 40 days after birth; but in females the decline in DNA concentration was more protracted, a...Continue Reading

References

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Citations

Jun 26, 1969·The New England Journal of Medicine·R A Malt
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A J OuelletteR A Malt
Mar 1, 1974·The British Journal of Nutrition·H S Fraser, G A Alleyne
Jun 1, 1969·The Journal of Cell Biology·G C Priestley, R A Malt
Aug 27, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Oliver WesselyDaniel Romaker
Apr 2, 1976·Biochimica Et Biophysica Acta·A J OuelletteR A Malt
Jul 27, 1976·Biochemistry·A J Ouellett, R A Malt
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·O Skraastad
Oct 26, 1976·Biochimica Et Biophysica Acta·P R McIntosh, K O'Toole
Sep 17, 1969·Biochimica Et Biophysica Acta·G C PriestleyR A Malt
Jul 1, 1973·Kidney International·D F Paulson, E E Fraley

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