PMID: 589472Dec 16, 1977

Development of the oculomotor nucleus, with special reference to the time of cell origin and cell death

Brain Research
G S Sohal

Abstract

The developmental pattern of the oculomotor nucleus from day 7 of incubation through two weeks after hatching was studied in white Peking duck embryos. The neuroblasts comprising the nucleus complete their last phase of DNA synthesis on days 4 and 5 and the anlage first appears on day 7. The various subnuclei become identifiable as distinct cell groups on day 8 or 9. There is a cell migration between the ventral-most portions of the two ventromedial nuclei on days 9 through 11, and as a result a well-developed oculomotor commissure is established between these two subnuclei. The maximum number of cells in the nucleus is present on day 11. There is a normally occurring overall loss of approximately 43% of the cells during ontogenesis. Cell death appears to be random, without any gradient, and virtually all of it occurs between days 11 and 15. Although the duration of cell death is essentially similar in all subnuclei, great variations exist in its magnitude. For example, there is a cell loss of approximately 61% in the accessory nucleus, 38% in the dorsolateral nucleus, 40% in the dorsomedial nucleus and 33% in the ventromedial nucleus. Cell loss in the oculomotor nucleus is compared with that observed in the other two eye-muscl...Continue Reading

Citations

Feb 1, 1978·The American Journal of Anatomy·R K Holt, G S Sohal
Jul 1, 1977·Experimental Neurology·G S Sohal, R K Holt
Apr 1, 1978·Experimental Neurology·G S SohalS D Stoney
May 1, 1995·Survey of Ophthalmology·J D PorterJ K Brueckner
Mar 10, 1978·Brain Research·G S Sohal, T A Weidman
Jun 1, 1981·The Journal of Comparative Neurology·M B Heaton
Dec 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Jonathan J Henry, Mark Q Martindale
Oct 1, 1984·Zentralblatt für Veterinärmedizin. Reihe A·A Muttini

Related Concepts

Accessory Nerve Structure
Cell Density
Cell Survival
Ducks
Oculomotor Nerve Structure
Optic Lobe, Human

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