Development of the pioneer sympathetic innervation into the dental pulp of the mouse mandibular first molar

Archives of Oral Biology
Kyaw MoeKeijo Luukko

Abstract

Our goal was to study the development of pioneer sympathetic innervation of dental pulp of mouse mandibular first molar. We used double fluorescent immunohistochemistry with tyrosine hydroxylase (TH) and anti-medium-chain neurofilament (2H3) antibodies to detect sympathetic and sensory nerve fibres. Serial sections of whole teeth from postnatal days (PN) 0-14, trigeminal and sympathetic superior cervical ganglia of PN 15 mice were examined with confocal microscope. There were two main findings. The unexpected finding was that 2H3 antibody was specific only for sensory nerve fibres and neurons and failed to stain either sympathetic nerve fibres or neurons. The main finding was that although both sympathetic and sensory nerve fibres were already seen near the tooth germ at the newborn stage, the pioneer sympathetic nerve fibres were first observed in the dental pulp only after the onset of root formation on day 9, in contrast to sensory nerve fibres which entered the tooth already on day 4. Pioneer sympathetic innervation of dental pulp starts on postnatal day 9 and follows sensory innervation. This indicates differential developmental regulation of the initial sensory and sympathetic innervation of teeth and provides essential b...Continue Reading

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Citations

Nov 13, 2012·Differentiation; Research in Biological Diversity·Kyaw MoeKeijo Luukko
Feb 6, 2014·Australian Dental Journal·H LesotR Peterkova
May 29, 2015·Journal of Anatomy·Jeroen CruckeAnn Huysseune
Sep 10, 2014·Frontiers in Physiology·Pierfrancesco PagellaThimios A Mitsiadis
Apr 14, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tadatoshi MatsubayashiShin-Ichi Abe
Feb 13, 2018·Journal of Tissue Engineering and Regenerative Medicine·Sabine Kuchler-BoppLaetitia Keller
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Eva SvandovaHerve Lesot

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