Development of the pulmonary surfactant system in the green sea turtle, Chelonia mydas

Respiration Physiology
S D JohnstonD T Booth

Abstract

This study describes the developmental changes in pulmonary surfactant (PS) lipids throughout incubation in the sea turtle, Chelonia mydas. Total phospholipid (PL), disaturated phospholipid (DSP) and cholesterol (Chol) harvested from lung washings increased with advancing incubation, where secretion was maximal at pipping, coincident with the onset of pulmonary ventilation. The DSP/PL ratio increased, whereas the Chol/PL and the Chol/DSP ratio declined throughout development. The phospholipids, therefore, are independently regulated from Chol and their development matches that of mammals. To explore whether hypoxia could elicit an effect on the development of the PS system, embryos were exposed to a chronic dose of 17% O2 for the final approximately 40% of incubation. Hypoxia did not affect incubation time, absolute, nor relative abundance of the surfactant lipids, demonstrating that the development of the system is robust and that embryonic development continues unabated under mild hypoxia. Hypoxia-incubated hatchlings had lighter wet lung weights than those from normoxia, inferring that mild hypoxia facilitates lung clearance in this species.

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Citations

May 19, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Chiu-Lin ChenI-Jiunn Cheng
May 23, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S D Johnston, C B Daniels
Nov 22, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Lucy C SullivanChristopher B Daniels
May 6, 2003·Reproduction, Fertility, and Development·Sandra OrgeigLucy C Sullivan
Feb 23, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Michael B Thompson
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lucy C SullivanChristopher B Daniels
May 1, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helen A BlackerChristopher B Daniels

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