PMID: 7547365Jan 1, 1995Paper

Development of the surfactant system

Pediatric Pulmonology. Supplement
J R Bourbon

Abstract

Pulmonary surfactant is a lipoprotein complex produced by type II pneumocytes that lines and stabilizes alveoli. Surfactant-specific proteins are early markers of the embryonic lung. Precursors of type II pneumocytes appear to be committed early and are able to pursue their differentiation program in a relatively autonomous way. Despite this potential, surfactant ontogeny and storage actually take place relatively late in the course of fetal development. Surfactant accumulation is, therefore, delayed until a certain stage after which it is stimulated by a number of factors. Recent investigations have pointed out the possible role of paracrine mechanisms in the determinism of this control, especially with regard to retinoids and TGF-beta.

References

Dec 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·I Gross, C M Wilson
Feb 1, 1994·American Journal of Respiratory Cell and Molecular Biology·J WangM Post
Sep 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A KhoorM T Stahlman

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