Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT)

Colloids and Surfaces. B, Biointerfaces
Chun-Yi WuWei-Ying Kuo

Abstract

Successful boron neutron capture therapy (BNCT) requires sufficient and specific delivery of boron atoms to malignant cells. Gold nanoparticles (AuNPs) have been used as a useful delivery system for selectively releasing cytotoxic payloads in the tumor. However, studies demonstrating the in vivo distribution or pharmacokinetics of boron-containing AuNPs via noninvasive imaging are lacking. This study aims to develop theranostic AuNP-boron cage assemblies (B-AuNPs) and evaluate its feasibility for BNCT. The commercial citrate-coated AuNPs were subjected to PEGylation, azide addition, and carborane modification on the surface. To further arm the AuNPs, we conjugated anti-HER2 antibody (61 IgG) with boron-containing PEGylated AuNPs to form 61-B-AuNPs. The diameter and radiolabeling efficiency of boron-containing AuNPs were determined by dynamic light scattering (DLS) and radio thin-layer chromatography (radio TLC), respectively. Noninvasive single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging was performed to determine the pharmacokinetics of radioiodinated AuNPs in N87 gastric cancer xenografts, and the content of boron in tumor and muscle was assessed by inductively coupled plasma mass spectrometry...Continue Reading

Citations

Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krishna R PulagamJordi Llop
Sep 23, 2020·Chemical Communications : Chem Comm·Jing YanYi Yan
Feb 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fayaz AliYinghuai Zhu
Dec 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Irene V J FeinerJordi Llop
Jan 26, 2021·Chemical Society Reviews·Juan PellicoRafael T M de Rosales
Dec 17, 2020·Frontiers in Molecular Biosciences·Gennaro SanitàAnnalisa Lamberti
Jan 29, 2021·ChemMedChem·Marta GozziEvamarie Hey-Hawkins
May 1, 2021·Life·Wolfgang A G SauerweinAndrea Wittig
Jul 6, 2021·International Journal of Biological Macromolecules·Jamileh KadkhodaAyuob Aghanejad

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