Development of thermodynamically stable nanostructured lipid carrier system using central composite design for zero order permeation of econazole nitrate through epidermis

Pharmaceutical Development and Technology
Lav Keshri, Kamla Pathak

Abstract

The investigation was aimed at developing thermodynamically stable topical delivery system of nanostructured lipid carrier of econazole nitrate (EN) for the treatment of deep seated fungal infection by improving its permeability. Fifteen formulations (F1-F15) of nanostructured lipid carriers (NLCs) were prepared by solvent injection technique using central composite design and characterized for particle size and % entrapment efficiency. Closeness in the results, guided the selection of five NLC formulations which were formulated as hydrogels (G1-G5) using Carbopol 934. The permeation studies of gels demonstrated G3 with flux rate of 3.21 ± 0.03 µg/cm(2)/min (> target flux of 1.46 µg/cm(2)/min) as the best formulation that exhibited zero order permeation. The amount of drug/unit area demonstrated linear dependency on flux rate. Confocal laser scanning microscopy demonstrated penetration of rhodamine red till the stratum basale due to hydration of stratum corneum. Hydrogel G3 containing NLC formulation (F5) was selected as the optimized topical gel. TEM of F5 revealed spherical particles that presented low recrystallization index of 72.35%. Stability profile for 90 days revealed insignificant change (p < 0.05) in the particle siz...Continue Reading

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Citations

Sep 28, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Ana BeloquiVéronique Préat
Dec 3, 2014·International Journal of Pharmaceutics·Monika JoshiKamla Pathak
Oct 21, 2016·Mycoses·Joaquim Suñer-CarbóAna Cristina Calpena-Campmany
Dec 15, 2018·Pharmacological Reports : PR·Anna Czajkowska-KośnikKatarzyna Winnicka
May 20, 2017·Journal of Drug Targeting·Mahima Mathur, V Kusum Devi

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