Development of Three Different NK Cell Subpopulations during Immune Reconstitution after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: Prognostic Markers in GvHD and Viral Infections

Frontiers in Immunology
Sabine HueneckeMelanie Bremm


Natural killer (NK) cells play an important role following allogeneic hematopoietic stem cell transplantation (HSCT) exerting graft-versus-leukemia/tumor effect and mediating pathogen-specific immunity. Although NK cells are the first donor-derived lymphocytes reconstituting post-HSCT, their distribution of CD56(++)CD16(-) (CD56(bright)), CD56(++)CD16(+) (CD56(intermediate=int)), and CD56(+)CD16(++) (CD56(dim)) NK cells is explicitly divergent from healthy adults, but to some extent comparable to the NK cell development in early childhood. The proportion of CD56(bright)/CD56(int)/CD56(dim) changed from 15/8/78% in early childhood to 6/4/90% in adults, respectively. Within this study, we first compared the NK cell reconstitution post-HSCT to reference values of NK cell subpopulations of healthy children. Afterward, we investigated the reconstitution of NK cell subpopulations post-HSCT in correlation to acute graft versus host disease (aGvHD) and chronic graft versus host disease (cGvHD) as well as to viral infections. Interestingly, after a HSCT follow-up phase of 12 months, the distribution of NK cell subpopulations largely matched the 50th percentile of the reference range for healthy individuals. Patients suffering from aGvHD...Continue Reading


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Nov 26, 2015·Frontiers in Immunology·Angela GismondiAngela Santoni

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Apr 10, 2018·Expert Review of Clinical Immunology·Hong-Gang RenSophie Paczesny
Sep 28, 2018·Bone Marrow Transplantation·Shahrzad BakhtiarPeter Bader
May 11, 2017·Frontiers in Immunology·Federico SimonettaRobert S Negrin
Jan 9, 2021·Journal of Immunological Methods·Melanie BremmSabine Huenecke

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flow cytometry

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