Development of thymic carcinoma in transgenic mice expressing SV40 T antigen

Cancer Letters
W Y ParkJ S Seo

Abstract

We produced transgenic mice using SV40 Tag gene under the control of its own enhancer and promoter. Three transgenic lines (SNU-SVT125, 127, 248) consistently developed thymic carcinoma as well as choroid plexus carcinoma and dysplastic renal tubule. In SNU-SVT248 line, SV40 Tag transgene was expressed at thymus, spleen and kidney. Thymic epithelium showed high level expression of SV40 Tag in immunohistochemistry. Histopathological and electron microscopic analysis revealed that poorly differentiated carcinoma was derived from type 2 to 4 thymic epithelial cell. Our transgenic mice would provide a model for studies on the pathogenesis of thymic carcinoma and on the regulation of thymopoiesis by epithelial cells.

References

Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P S JatD Kioussis
Feb 1, 1991·Immunology Today·R L Boyd, P Hugo

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Citations

Oct 1, 1995·The Annals of Thoracic Surgery·D BlumbergV Rusch
Feb 13, 2014·International Journal of Biological Sciences·Jiang-chao LiLi-jing Wang
May 26, 2009·Journal of Cancer Research and Clinical Oncology·Hua-chuan ZhengYasuo Takano
Jun 24, 2015·Oncotarget·Chih-Chia LiangChun-Ming Chen

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