Development of tolerance to the dietary plant secondary metabolite 1,8-cineole by the brushtail possum (Trichosurus vulpecula).

Journal of Chemical Ecology
Stuart McLeanNatasha Wiggins

Abstract

The common brushtail possum (Trichosurus vulpecula) is a generalist herbivore whose diet includes Eucalyptus leaves that are well defended by plant secondary metabolites (PSM) such as the terpene 1,8-cineole (cineole). We accustomed possums to a terpene-free diet, then challenged them with the addition of 2% cineole to the diet. Initially, there was a 50% reduction in total overnight food consumption associated with a marked decrease in the mass of the major feeding bout. After nine nights, however, cineole tolerance had developed as total food consumption had returned to the control amount. Compared to the control diet, the cineole diet was eaten in a larger number of smaller bouts, which were also eaten at a slower rate. The experiment was repeated with animals that had been accustomed to day-time feeding to take blood samples during feeding sessions. Feeding variables and blood concentration data for cineole were compared on the first and seventh day of the cineole diet. Although the total food consumed increased 2.5-fold after 7 days of the cineole diet, there was no increase in average blood cineole concentration, measured as the area under the concentration-time curve. This indicates that induction of liver enzymes result...Continue Reading

References

Aug 1, 1996·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·M J Snyder, J I Glendinning
Jan 1, 1999·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·I R LawlerB M Eschler
Feb 8, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·G J PassI Stupans
Jul 9, 2002·British Journal of Clinical Pharmacology·Robin Spiller
Aug 6, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Ioannides
Oct 29, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Rebecca R BoyleNoel W Davies
Dec 5, 2002·Archives of Biochemistry and Biophysics·Frank J Gonzalez, Shioko Kimura
Mar 15, 2003·Drug Metabolism Reviews·Shufeng ZhouJames W Paxton
Oct 9, 2003·Clinical Pharmacokinetics·Robert Z HarrisShirley Tsunoda
Dec 17, 2003·Clinical Pharmacokinetics·Hongbing Wang, Edward L LeCluyse
Jul 21, 2004·Journal of Chemical Ecology·Rebecca R Boyle, Stuart McLean
Jan 28, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J M PascussiP Maurel
May 10, 2005·The Proceedings of the Nutrition Society·Glenn Iason
Apr 6, 2006·Journal of Chemical Ecology·Luthando E DzibaFrederick D Provenza
Sep 27, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S McLeanJ S Sorensen

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Citations

Feb 16, 2011·Journal of Animal Physiology and Animal Nutrition·I PoulopoulouI Hadjigeorgiou
Oct 1, 2012·Asian-Australasian Journal of Animal Sciences·I PoulopoulouI Hadjigeorgiou
Oct 4, 2019·The Journal of Animal Ecology·Hannah R Windley, Takuya Shimada

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