Development of treatment for advanced colorectal cancer: infusional 5-FU and the role of new agents

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
H J Schmoll

Abstract

Despite the fact that it was first introduced as a cancer treatment over 30 years ago, the mainstay cytotoxic agent for the treatment of metastatic colonic cancer is still 5-fluorouracil (5-FU). However, even after all this time, there is still no standard schedule for 5-FU administration which is recognised by the oncology profession. Bolus infusion remains the most popular choice, but recent investigations into short- and long-term continuous infusion schedules of 5-FU have offered advantages in terms of objective response rates and toxicity. In addition, combination infusion regimens (whereby the effectiveness of 5-FU is modulated through its co-administration with other agents or chronomodulation) are becoming accepted, although, once again, there is no recognised standard treatment regimen. This paper reviews the data from those non-comparative studies in which 5-FU has been administered as monotherapy, and relates this to data from studies of 5-FU co-administration with folinic acid and interferon. Data from other treatment regimens, which include topoisomerase I inhibitor schedules and chronomodulation of 5-FU with oxaliplatin, are presented. The advantages and disadvantages of these different regimens based upon these n...Continue Reading

Citations

Apr 21, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Cunningham, R D James
Apr 6, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C TwelvesUNKNOWN Xeloda Colorectal Cancer Study Group
Jun 1, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E M BraunE M Lishchishina
Nov 7, 2003·Oncology Nursing Forum·Deborah Berg
Sep 3, 2004·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Cora N SternbergMichelle Holland
Oct 18, 2001·Anti-cancer Drugs·P G Johnston, S Kaye
Nov 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Van CutsemUNKNOWN Xeloda Colorectal Cancer Study Group
Dec 4, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Y ShirotaH J Lenz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.