PMID: 2493381Jan 1, 1989Paper

Development of tumour cell resistance to tumour necrosis factor does not confer resistance to cytotoxic drugs

European Journal of Cancer & Clinical Oncology
M L Neale, N Matthews

Abstract

Tumour necrosis factor (TNF) is a protein product of macrophages with potential anti-cancer activity. As with other anti-cancer agents, tumour cells can develop resistance to the cytotoxic effects of TNF. The aim of his study was to see whether development of resistance to TNF resulted in a concomitant resistance to other anti-cancer agents, in particular those associated with multidrug resistance. Three TNF-susceptible tumour cell lines (L929, U937 and RK13) and their TNF-resistant sublines were compared for susceptibility in vitro to several cytotoxic drugs. The TNF-resistant sublines were not significantly more resistant to these drugs. In addition, an L929 subline selected for resistance to actinomycin D retained its susceptibility to TNF. These observations show that tumour cell resistance to TNF develops independently of resistance to cytotoxic drugs.

References

Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
Mar 1, 1985·European Journal of Immunology·N Matthews
Mar 30, 1984·Journal of Immunological Methods·D A Flick, G E Gifford
Jan 1, 1981·Infection and Immunity·M R Ruff, G E Gifford

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Citations

Jul 6, 2000·Journal of Physiology and Biochemistry·M J Ruiz GómezM Martínez Morillo

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