Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus

International Journal of Experimental Diabesity Research
Bo NiklassonÅke Lernmark

Abstract

Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P = .03) autoantibodies. Affected islets stained positive for Ljungan virus, a novel picorna virus isolated from bank voles. Ljungan virus inoculation of nondiabetic wild bank voles induced beta-cell lysis. Compared to group A bank voles, Ljungan vi...Continue Reading

Citations

May 2, 2009·Forensic Science, Medicine, and Pathology·Bo NiklassonWilliam Klitz
Jun 6, 2008·Journal of Clinical Microbiology·W Allan NixM Steven Oberste
Jul 13, 2012·Journal of Virology·Virginie SauvageMarc Eloit
Apr 11, 2013·PloS One·Colin R MuirheadRichard J Q McNally
Mar 19, 2014·Diabetes Management·Darius A Schneider, Matthias G von Herrath
May 15, 2013·Archives of Virology·Anne-Marie SalisburyJames P Stewart
Jul 31, 2014·Diabetologia·Darius A Schneider, Matthias G von Herrath
Jan 13, 2015·Journal of Pathogens·Jana PrecechtelovaShubhada Bopegamage
Feb 10, 2010·International Journal of Diabetes in Developing Countries·Oindrila RahaV R Rao
May 15, 2012·Journal of Virological Methods·René KalliesMatthias Niedrig
May 18, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W Allan NixM Steven Oberste
Jul 16, 2013·Journal of Medical Virology·Anne J JääskeläinenOlli Vapalahti
Apr 12, 2008·Journal of Virological Methods·Conny TolfA Michael Lindberg
Sep 17, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kieran C PounderLorraine M McElhinney
Jan 31, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Jan 6, 2009·Annals of the New York Academy of Sciences·Sreevalsam GopinathCarani B Sanjeevi
Aug 21, 2008·Journal of Medical Virology·German TapiaKjersti S Rønningen
Jul 16, 2013·Journal of Medical Virology·P KolehmainenSisko Tauriainen
Apr 7, 2011·Pediatric Diabetes·Jeanette WahlbergABIS Study Group
Apr 20, 2004·Biochemical and Biophysical Research Communications·E Susanne JohanssonA Michael Lindberg
Oct 12, 2005·Current Opinion in Immunology·Margo Honeyman
Jan 8, 2013·General and Comparative Endocrinology·Aleksandra BartelikAlicja Józkowicz
Jul 22, 2016·Lab Animal·Gregory D Larsen
Aug 10, 2016·Viral Immunology·Bo NiklassonWilliam Klitz
Feb 22, 2007·Journal of Medical Virology·Sisko TauriainenHeikki Hyöty
Feb 14, 2017·Journal of Wildlife Diseases·Cristina FevolaHeidi C Hauffe
Jul 18, 2018·Pediatric Diabetes·Åshild Olsen Faresjö, Johnny Ludvigsson
Aug 9, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeBo Niklasson
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Oct 5, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Henry F Krous, Neil E Langlois
Jun 27, 2020·JAD Reports·Bo NiklassonElisabet Englund
Jun 4, 2020·Vector Borne and Zoonotic Diseases·Cristina FevolaHeidi C Hauffe
Dec 1, 2020·PLoS Pathogens·Feifei ZhangMark E J Woolhouse

Related Concepts

Gad2 protein, rat
Teens
Metazoa
Antibodies, Viral
Autoantibodies
Ondatra
Diabetes, Autoimmune
Glutamate Decarboxylase
Insulin Antibodies
Islets of Langerhans

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.