PMID: 8459097Mar 1, 1993Paper

Development of vagal innervation to the muscle of the avian gizzard

Journal of the Autonomic Nervous System
H OhashiS Komori

Abstract

The development of the vagal innervation to the gizzard has been investigated in chick embryos and young chicks. The membrane potential, first measurable on the 15th day of incubation, was -54 +/- 0.5 mV and increased with development to -67 +/- 0.4 mV. The latter value was attained 5 days after hatching and persisted thereafter. Stimulation of intramural nerves elicited a cholinergic, excitatory junction potential (EJP) for the first time, only in a small fraction of cells, on the 20th day of incubation. Within 3 days after hatching, cholinergic transmission showed the same features as in older chicks. Stimulation of the vagus nerve elicited no membrane potential responses before hatching but as early as 4 days after hatching, non-adrenergic, inhibitory junction potentials (IJPs) were evoked. In the next 10 days or so, the IJP was replaced with a cholinergic EJP as seen in mature tissues. After atropine (0.1-1 microM) treatment, both vagal and intramural nerve stimulation evoked a non-adrenergic IJP in a small fraction of cells immediately after hatching. The fraction of cells exhibiting the IJP increased with growth and reached 100% 5 days after hatching. Hexamethonium (50 or 100 microM) abolished the vagally-evoked EJPs. The...Continue Reading

References

Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·N M Le DouarinG H Le Douarin
Mar 1, 1989·British Journal of Pharmacology·H MiyazakiA Ohga
Sep 1, 1970·Japanese Journal of Pharmacology·H SatoY Nakazato
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Bennett
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Bennett, J L Cobb

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