Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells

The Journal of Infectious Diseases
Ling ShenZheng W Chen

Abstract

Vgamma2Vdelta2+ T cells play a role in antimicrobial responses. It is unknown whether adaptive Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of human immunodeficiency virus-infected humans can be generated during effective antiretroviral treatment. Here, simian immunodeficiency virus (SIV)mac-infected macaques previously exposed to bacille Calmette-Guerin (BCG) were reinfected with BCG, were treated either with tenofovir or tenofovir plus indinavir, and were assessed for the development of Vgamma2Vdelta2+ T cell responses during active BCG coinfection. A restored capacity of Vgamma2Vdelta2+ T cells to undergo major expansions and pulmonary migration during active BCG coinfection was detected after simultaneous BCG reinfection and treatment with tenofovir of the SIVmac-infected macaques. Interestingly, a restored expansion of Vgamma2Vdelta2+ T cells in the SIVmac/BCG-coinfected macaques was detectable, even though antiretroviral treatment was initiated 1 month after BCG reinfection. Importantly, the restored expansion of Vgamma2Vdelta2+ T cells coincided with increases in numbers of purified protein derivative-specific interferon- gamma -producing CD4+ T cells and increases in the magnitude of their pr...Continue Reading

References

Nov 7, 2001·The Journal of Clinical Investigation·L WangJ F Bukowski
Feb 13, 2003·AIDS Research and Human Retroviruses·Patrick J EndersC David Pauza
Apr 17, 2003·Trends in Immunology·Zheng W Chen, Norman L Letvin
Jul 19, 2003·Clinical and Experimental Immunology·X LaiZ W Chen

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Citations

Jun 15, 2011·Cellular and Molecular Life Sciences : CMLS·Zheng W Chen
Jun 26, 2013·Immunology and Cell Biology·Daniel W FowlerMark D Bodman-Smith
Dec 8, 2006·The Journal of Infectious Diseases·Dan HuangZheng W Chen
Nov 28, 2017·Cellular & Molecular Immunology·Hongbo Shen, Zheng W Chen
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zahida AliZheng W Chen
Mar 21, 2012·Journal of Medical Primatology·D KaushalA A Lackner
Sep 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne BourgaritUNKNOWN PARADOX Study Group
Jul 20, 2019·Clinical & Translational Immunology·Jennifer A Juno, Emily M Eriksson

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