Development of visual category selectivity in ventral visual cortex does not require visual experience

Proceedings of the National Academy of Sciences of the United States of America
Job van den HurkHans P Op de Beeck

Abstract

To what extent does functional brain organization rely on sensory input? Here, we show that for the penultimate visual-processing region, ventral-temporal cortex (VTC), visual experience is not the origin of its fundamental organizational property, category selectivity. In the fMRI study reported here, we presented 14 congenitally blind participants with face-, body-, scene-, and object-related natural sounds and presented 20 healthy controls with both auditory and visual stimuli from these categories. Using macroanatomical alignment, response mapping, and surface-based multivoxel pattern analysis, we demonstrated that VTC in blind individuals shows robust discriminatory responses elicited by the four categories and that these patterns of activity in blind subjects could successfully predict the visual categories in sighted controls. These findings were confirmed in a subset of blind participants born without eyes and thus deprived from all light perception since conception. The sounds also could be decoded in primary visual and primary auditory cortex, but these regions did not sustain generalization across modalities. Surprisingly, although not as strong as visual responses, selectivity for auditory stimulation in visual cort...Continue Reading

References

Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·R MalachR B Tootell
Apr 29, 1998·Nature·R Epstein, N Kanwisher
Apr 15, 1999·Annual Review of Neuroscience·R O Wong
Apr 25, 2001·Nature Neuroscience·I LevyR Malach
Apr 27, 2001·Vision Research·K Grill-SpectorN Kanwisher
Sep 29, 2001·Science·P E DowningN Kanwisher
Jun 4, 2002·Nature Reviews. Neuroscience·Daphne Bavelier, Helen J Neville
May 15, 2003·Current Opinion in Neurobiology·Kalanit Grill-Spector
Apr 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pietro PietriniJames V Haxby
Apr 27, 2005·Nature Neuroscience·Yukiyasu Kamitani, Frank Tong
Jul 19, 2005·Annual Review of Neuroscience·Alvaro Pascual-LeoneLotfi B Merabet
Nov 17, 2005·Nature Reviews. Neuroscience·Giorgio M Innocenti, David J Price
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca F SchwarzloseNancy Kanwisher
Jun 23, 2006·Nature Reviews. Neuroscience·John-Dylan Haynes, Geraint Rees
Nov 23, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nancy Kanwisher, Galit Yovel
Nov 28, 2007·Orphanet Journal of Rare Diseases·Amit S Verma, David R Fitzpatrick
Jan 18, 2008·Nature Reviews. Neuroscience·Hans P Op de BeeckNancy G Kanwisher
May 9, 2008·Journal of Neurophysiology·Rory Sayres, Kalanit Grill-Spector
Nov 5, 2008·Frontiers in Neuroscience·Alexander Borst
Nov 26, 2009·Nature Reviews. Neuroscience·Lotfi B Merabet, Alvaro Pascual-Leone
Jul 30, 2010·Journal of Neurophysiology·Lindsay B LewisIone Fine
Jan 28, 2011·Journal of Cognitive Neuroscience·Susanne QuadfliegC Neil Macrae
Feb 22, 2011·Current Biology : CB·Lior ReichAmir Amedi
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier CollignonFranco Lepore
Feb 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew C ConnollyJames V Haxby
Mar 20, 2012·Brain : a Journal of Neurology·Kate E WatkinsHolly Bridge
Sep 1, 2012·Frontiers in Neuroinformatics·Hiroyuki AkamaMassimo Poesio
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kingson ManKaspar Meyer
Apr 20, 2013·Science·Sid KouiderGhislaine Dehaene-Lambertz
Jul 11, 2013·Neural Plasticity·Wen Qin, Chunshui Yu
Jul 24, 2013·Trends in Cognitive Sciences·Nikolaus Kriegeskorte, Rogier A Kievit
Oct 26, 2013·Neuroscience and Biobehavioral Reviews·Emiliano RicciardiPietro Pietrini
Nov 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kate E WatkinsHolly Bridge
Jan 8, 2014·Journal of Vision·Anouk J de BrouwerJeroen B J Smeets

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Citations

Jul 6, 2018·Annual Review of Vision Science·Ione Fine, Ji-Min Park
Sep 10, 2019·ELife·Sushrut ThoratMarius V Peelen
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Frederik S KampsDaniel D Dilks
Sep 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bria LongTalia Konkle
May 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Judy S KimMarina Bedny
Aug 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·N Apurva Ratan MurtyNancy Kanwisher
Sep 25, 2020·Cerebral Cortex·Mona RosenkeRainer Goebel
Sep 1, 2018·Cerebral Cortex·Gilles VannuscorpsAlfonso Caramazza
Jun 22, 2019·Annual Review of Vision Science·Michael J ArcaroMargaret S Livingstone
Sep 10, 2020·Journal of Neural Engineering·Chong WangHuafu Chen
Sep 24, 2020·Journal of Neurophysiology·Athena L HowellZeynep M Saygin
Dec 16, 2020·Human Brain Mapping·Maria ArioliZaira Cattaneo
Jul 28, 2020·Neuroscience and Biobehavioral Reviews·Virginie Crollen, Olivier Collignon
Nov 27, 2020·Neuroscience and Biobehavioral Reviews·Brigitte RöderMaria J S Guerreiro
Nov 3, 2020·Frontiers in Psychiatry·Silvia Sánchez-Ramón, Florence Faure
Oct 15, 2020·Scientific Reports·Jacob A MillerKevin S Weiner
Nov 5, 2020·Nature Reviews. Neuroscience·Janis K Hesse, Doris Y Tsao
Oct 24, 2020·Scientific Reports·Jin LiZeynep M Saygin
Jul 26, 2018·Trends in Cognitive Sciences·Lindsey J PowellRebecca Saxe
May 1, 2021·Journal of Neural Engineering·Mahshid FouladivandaArdalan Aarabi
May 21, 2021·Journal of the Association for Research in Otolaryngology : JARO·Collins Opoku-BaahMark T Wallace
Dec 20, 2020·Current Opinion in Neurobiology·Brigitte Röder, Ramesh Kekunnaya
Feb 6, 2020·Journal of Cognitive Neuroscience·Roberto BottiniOlivier Collignon
Aug 5, 2021·Nature Reviews. Neuroscience·Michael J Arcaro, Margaret S Livingstone
Dec 18, 2021·Nature Communications·Seungdae BaekSe-Bum Paik

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