Development of vitamin E-modified polysulfone membrane dialyzers.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Masatomi Sasaki

Abstract

Oxygen radicals have recently been attracting close attention because of their involvement in tissue damage and their close relationship to various clinical conditions. It has been suggested that hemodialysis increases oxidative stress, triggering the development of complications such as atherosclerosis and dialysis-related amyloidosis. We recently developed a dialyzer containing a highly functional polysulfone membrane on which vitamin E had been bonded (PS-ViE). The present study was undertaken to evaluate the biocompatibility of this membrane and to conduct other experiments on the membrane in vitro. Human blood was dialyzed with minidialyzers (300-600 cm(2) membrane area) made of PS-ViE, cellulose, or untreated polusulfone (PS), and the effects of the dialyzers on complements (C3a, C4a, and C5a), cytokines (IL-1beta and IL-8), and granulocyte elastase as well as their anti-oxidative activity were investigated (n = 6). The effect of PS-ViE on complement activation and its effects on cytokines were comparable to those of PS membrane, whereas granulocyte elastase following dialysis with the PS-ViE membrane tended to be lower than that seen with PS membrane. The effects of PS-ViE-induced methemoglobin, lipid peroxide, and oxyge...Continue Reading

References

Jan 12, 2000·Contributions to Nephrology·M SasakiM Saruhashi
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Citations

Feb 6, 2013·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroshi TsukaoHirosuke Kobayashi
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Jul 23, 2014·ACS Applied Materials & Interfaces·Chunming LiJinghua Yin
Apr 27, 2016·Carbohydrate Polymers·Vijay Kumar Thakur, Stefan Ioan Voicu
Oct 25, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohamed Shariful IslamVincent L M Esnault
Feb 18, 2009·The American Journal of Chinese Medicine·Tung-Sheng ChenYen-Lin Chang
Jun 19, 2007·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaH Watanabe
Mar 12, 2016·Biomedizinische Technik. Biomedical Engineering·Qinglei ZhangLihua Zhao
Jul 15, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Michaela KohlováMaria Conceição B S M Montenegro
Nov 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunming LiLigang Yin
Dec 11, 2007·The International Journal of Artificial Organs·N A Hoenich
Nov 18, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Kinue KamataToshinori Koizumi
Jun 5, 2021·Hemodialysis International·Adam M ZawadaJames P Kennedy

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