Development of white matter fibre density and morphology over childhood: A longitudinal fixel-based analysis

NeuroImage
Sila GencTimothy J Silk

Abstract

White matter fibre development in childhood involves dynamic changes to microstructural organisation driven by increasing axon diameter, density, and myelination. However, there is a lack of longitudinal studies that have quantified advanced diffusion metrics to identify regions of accelerated fibre maturation, particularly across the early pubertal period. We applied a novel longitudinal fixel-based analysis (FBA) framework, in order to estimate microscopic and macroscopic white matter changes over time. Diffusion-weighted imaging (DWI) data were acquired for 59 typically developing children (27 female) aged 9-13 years  at two time-points approximately 16 months apart (time-point 1: 10.4 ± 0.4 years, time-point 2: 11.7 ± 0.5 years). Whole brain FBA was performed using the connectivity-based fixel enhancement method, to assess longitudinal changes in fibre microscopic density and macroscopic morphological measures, and how these changes are related to sex, pubertal stage, and pubertal progression. Follow-up analyses were performed in sub-regions of the corpus callosum to confirm the main findings using a Bayesian repeated measures approach. There was a statistically significant increase in fibre density over time localised to m...Continue Reading

Citations

Sep 14, 2018·F1000Research·Diliana PechevaSerena J Counsell
Mar 28, 2020·Human Brain Mapping·Sila GencDerek K Jones
Jan 10, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Angeliki ZarkaliRimona S Weil
Nov 27, 2020·Journal of Affective Disorders·Daniel T BurleyTimothy J Silk
Sep 4, 2020·NeuroImage·Marjolein E A BarendseSarah Whittle
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Oct 26, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Dana KanelChiara Nosarti
Mar 31, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Ian FuelscherTimothy J Silk
Apr 16, 2021·Frontiers in Human Neuroscience·Shereif HaykalFrans W Cornelissen
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Jul 28, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Mervyn SinghChristian Hyde
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