Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations

Transfusion
Donald M MockJohn A Widness

Abstract

The current reference method in the United States for measuring in vivo population red blood cell (RBC) kinetics utilizes chromium-51 (51 Cr) RBC labeling for determining RBC volume, 24-hour posttransfusion RBC recovery, and long-term RBC survival. Here we provide evidence supporting adoption of a method for kinetics that uses the biotin-labeled RBCs (BioRBCs) as a superior, versatile method for both regulatory and investigational purposes. RBC kinetic analysis using BioRBCs has important methodologic, analytical, and safety advantages over 51 Cr-labeled RBCs. We critically review recent advances in labeling human RBCs at multiple and progressively lower biotin label densities for concurrent, accurate, and sensitive determination of both autologous and allogeneic RBC population kinetics. BioRBC methods valid for RBC kinetic studies, including successful variations used by the authors, are presented along with pharmacokinetic modeling approaches for the accurate determination of RBC pharmacokinetic variables in health and disease. The advantages and limitations of the BioRBC method-including its capability of determining multiple BioRBC densities simultaneously in the same individual throughout the entire RBC life span-are prese...Continue Reading

References

Apr 1, 1978·Clinical Nuclear Medicine·C Ricketts, I Cavill
Oct 26, 1999·Transfusion·D G CordleD M Mock
Mar 31, 2004·Analytical Biochemistry·Anna BogusiewiczDonald M Mock
Jul 4, 2008·Pediatric Research·Donald M MockJohn A Widness
Nov 26, 2008·American Journal of Hematology·Robert S Franco
Feb 28, 1919·The Journal of Experimental Medicine·W Ashby
Jan 11, 2012·Transfusion·John R Hess, UNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Mar 13, 2012·Transfusion·George Garratty
Nov 2, 2012·American Journal of Hematology·Robert S FrancoRobert M Cohen
Nov 23, 2012·Diabetes Care·Robert M Cohen, Christopher J Lindsell
Mar 29, 2014·European Journal of Microbiology & Immunology·O LiesenfeldG Kost
Jun 28, 2014·Transfusion Medicine Reviews·Donald M MockRobert S Franco
Jul 6, 2014·Journal of Medical Case Reports·Ester SimeonePaolo Antonio Ascierto
May 29, 2015·The AAPS Journal·Denison J KuruvillaPeter Veng-Pedersen
Aug 12, 2015·Transfusion·Steven L SpitalnikUNKNOWN State of the Science in Transfusion Medicine Working Groups
Jan 23, 2016·Melanoma Research·Benjamin Y KongMatteo S Carlino
Apr 4, 2016·Journal of Pharmacokinetics and Pharmacodynamics·Rajiv P ShresthaYossi Chait
Nov 20, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Penka S PetrovaRobert A Uger
Apr 30, 2017·Circulation. Heart Failure·David MonteroAndreas J Flammer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.