Developmental actions of natriuretic peptides in the brain and skeleton

Cellular and Molecular Life Sciences : CMLS
J A Waschek

Abstract

The concept that atrial natriuretic peptide (ANP) and the closely related peptides BNP and CNP might be involved in the ontogeny of several organ systems emerged in the late 1980s. While many of the reported in vitro actions have not been examined in the context of organ development in vivo, recent studies demonstrate that mice which lack or overexpress natriuretic peptides or receptors exhibit pronounced skeletal growth defects. This article discusses how natriuretic peptides and other factors appear to regulate bone growth as an example of how natriuretic peptides might participate in the ontogeny of other organ systems. Evidence indicating that natriuretic peptides regulate neural development is then reviewed. Natriuretic peptides and receptors exhibit complex expression patterns in the developing nervous system, where they have been shown to act on neural cells as early as at the embryonic neural tube stage. Interestingly, both bone and brain growth appear to utilize primarily CNP and the CNP-specific type B receptor, and perhaps the type C receptor. In vitro data indicate that CNP may act on developing neurons, astrocytes and Schwann cells like a classical growth factor, regulating proliferation, patterning, phenotypic spe...Continue Reading

Citations

Mar 23, 2010·Neurochemistry International·Judith PradoAgustina García
Jan 25, 2008·Progress in Neurobiology·Li-Hui Cao, Xiong-Li Yang
Jun 13, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·W M Merz, U Gembruch
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Jan 28, 2021·International Journal of Molecular Sciences·Samantha M MirczukRobert C Fowkes
Jul 9, 2021·Biomedical Journal·Mengjiao XuGeng Yang

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