PMID: 15252288Jul 15, 2004Paper

Developmental alcohol exposure alters light-induced phase shifts of the circadian activity rhythm in rats

Alcoholism, Clinical and Experimental Research
Yuhua Z FarnellDavid J Earnest

Abstract

Developmental alcohol (EtOH) exposure produces long-term changes in the photic regulation of rat circadian behavior. Because entrainment of circadian rhythms to 24-hr light/dark cycles is mediated by phase shifting or resetting the clock mechanism, we examined whether developmental EtOH exposure also alters the phase-shifting effects of light pulses on the rat activity rhythm. Artificially reared Sprague-Dawley rat pups were exposed to EtOH (4.5 g/kg/day) or an isocaloric milk formula (gastrostomy control; GC) on postnatal days 4 to 9. At 2 months of age, rats from the EtOH, GC, and suckle control groups were housed individually, and wheel-running behavior was continuously recorded first in a 12-hr light/12-hr dark photoperiod for 10 to 14 days and thereafter in constant darkness (DD). Once the activity rhythm was observed to stably free-run in DD for at least 14 days, animals were exposed to a 15-min light pulse at either 2 or 10 hr after the onset of activity [i.e., circadian time (CT) 14 or 22, respectively], because light exposure at these times induces maximal phase delays or advances of the rat activity rhythm. EtOH-treated rats were distinguished by robust increases in their phase-shifting responses to light. In the suck...Continue Reading

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Citations

Apr 6, 2006·Cancer Causes & Control : CCC·Richard G Stevens
Apr 7, 2005·Physiology & Behavior·Alan M RosenwasserRyan W Logan
Apr 11, 2008·Early Human Development·Marcia TroeseMarie J Hayes
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Gregg C AllenDavid J Earnest
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Rainer SpanagelDipak K Sarkar
Jun 2, 2006·Alcoholism, Clinical and Experimental Research·Alvaro ArjonaDipak K Sarkar
Apr 26, 2006·Alcoholism, Clinical and Experimental Research·Hiromi Sakata-HagaJennifer D Thomas
Jan 6, 2012·Chronobiology International·Deirdre A ConroyKirk J Brower
Jun 1, 2018·Alcoholism, Clinical and Experimental Research·Sarah M Inkelis, Jennifer D Thomas
Jul 19, 2005·Chronobiology International·Alan M RosenwasserMatthew E Fecteau

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