Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis

Journal of Neurovirology
David DietzMikhail V Pletnikov

Abstract

Neonatal Borna disease virus (BDV) infection of the rat brain serves as a valuable model for studying the pathogenesis of neurodevelopmental abnormalities following early brain injury. Previous experiments have demonstrated significant alterations in regional tissue content of serotonin (5-HT) in neonatally BDV-infected Lewis rats. The present study sought to provide more insights into postnatal virus-associated alterations in 5-HT neurotransmission by evaluating the density of 5-HT1a receptors in the hippocampus and 5-HT2a receptors in the cortex, regional 5-HT tissue concentrations, behavioral responses to a 5-HT agonist, quipazine, and numbers of neurons in specific subfields of the hippocampus on days 7, 14, and 30 after neonatal BDV infection in Lewis rats. Neonatal BDV infection was found to be associated with a gradual increase in the density of 5-HT2a and 5-HT1a postsynaptic receptors followed by an elevation of 5-HT contents at both the levels of synaptic terminals (i.e., cortex and hippocampus) and cell bodies (i.e., raphe nuclei). In addition, there was an enhanced behavioral response to quipazine. Virus-associated neurochemical and behavioral changes were accompanied by a decline in the number of neurons in the dent...Continue Reading

Citations

May 12, 2005·Virus Research·Daniel Gonzalez-DuniaMartin Schwemmle
May 22, 2010·Interdisciplinary Perspectives on Infectious Diseases·Marco Bortolato, Sean C Godar
Mar 6, 2010·Interdisciplinary Perspectives on Infectious Diseases·Marylou V Solbrig
Jul 7, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·K Bechter

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