PMID: 9187481Jun 1, 1997Paper

Developmental and aging changes in the expression of amyloid precursor protein in Down syndrome brains

Brain & Development
Y AraiS Takashima

Abstract

We studied immunohistochemically the expression of beta-amyloid precursor protein (APP) in the frontal lobes of 18 Down syndrome (DS) patients (20 gestation weeks (GW) to 50 years) and 15 controls (17 GW to 50 years) using six purified antibodies against the secretory forms (N-terminal, N-Amy and Amy540), the Kunitz-type protease inhibitor (KPI) domain, residues 1-28 of beta protein (Affi28), and the carboxyl-terminal fragment (Ac) of APP. In the cortex of fetuses, neonates and infants, immunoreactivity for N-Amy and Ac was observed in both neurons and glial cells, and that for Affi28 in glial cells in the subpial layer in both DS patients and controls suggesting the functioning role of APP was a growth factor. This immunoreactivity disappeared in childhood and reappeared in adulthood in only DS patients. The earlier reappearance of those in DS patients from a young adult age than in normal controls may result from a gene dosage effect, since APP is encoded on chromosome 21. The N-Amy, Amy540, Affi28 and Ac immunoreactivity in glial cells in the developing white matter in the both DS patients and controls may be associated with myelination glia. Immunoreactivity for KPI was noted on the tunica media of the arteries from the neo...Continue Reading

References

Apr 1, 1991·Neuron·D J Selkoe
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E H KooD L Price
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jan 1, 1983·Archives of Neurology·S Takashima, L E Becker
Jul 14, 1995·Brain Research. Developmental Brain Research·Y AraiS Takashima

❮ Previous
Next ❯

Citations

Sep 13, 2001·Mental Retardation and Developmental Disabilities Research Reviews·I T Lott, E Head
Mar 14, 2002·Brain & Development·Yasuhiro AraiSachio Takashima
Dec 18, 2003·Neurobiology of Disease·E J WolvetangP J Hertzog
Jan 19, 2011·Neuroscience Letters·Yong-Lin JiaYan-Jie Jia
Oct 26, 2007·Biochemical and Biophysical Research Communications·Prashob PorayetteCraig S Atwood
Mar 10, 2001·Reviews in the Neurosciences·P K Panegyres
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Apr 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura J Vella, Roberto Cappai
Feb 27, 2003·Journal of Neurochemistry·Ephrem Engidawork, Gert Lubec
Apr 9, 2005·Early Human Development·Jose L Bartha, Peter W Soothill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.