Developmental and epigenetic regulation of the human TLR3 gene.

Molecular Immunology
Analia PorrásBruce H Howard

Abstract

The receptor encoded by the human TLR3 gene recognizes double-strand RNAs (dsRNAs) associated with viral infection. TLR3 expression is strongly activated upon differentiation of monocytes to dendritic cells, and can be further stimulated by the dsRNA analog polyinosine:polycytosine (PI:C). We report evidence for developmental regulation of the TLR3 gene. In dendritic cells derived from cord blood, both differentiation- and PI:C-associated TLR3 transcriptional activation are impaired as compared to cells from adults. Consistent with relative expression patterns, chromatin states and remodeling differ between newborn and adult samples. TLR3 expression in newborn dendritic cells exhibits heterocellularity and allelic imbalance (skewing), features characteristic of cis-acting epigenetic control. These findings reveal a new source for variability in innate immune system function and provide a model for further study of perinatal epigenetic transitions during development.

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Citations

Apr 13, 2012·Nucleic Acids Research·Paraskevi SalpeaBruce H Howard
Aug 29, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ashish Arunkumar SharmaPascal M Lavoie
Jan 7, 2017·Pediatric Research·David N O'DriscollCatherine M Greene
Aug 12, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroWade T Rogers
Feb 13, 2018·Biomedical Reports·Jinjing GuZhe Lu
Aug 1, 2013·Journal of Leukocyte Biology·Lucija SlavicaKristina Eriksson
Mar 9, 2018·Frontiers in Immunology·Wendy FonsecaCatherine Ptaschinski
Oct 30, 2020·Animals : an Open Access Journal From MDPI·Anna MigdałAnna Chełmońska-Soyta
Jan 24, 2021·Seminars in Cancer Biology·Mohammad Imran KhanHasan Mukhtar
Aug 14, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ryan A HladyKeith D Robertson

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