Developmental and genetic components explain enhanced pulmonary volumes of female Peruvian Quechua

American Journal of Physical Anthropology
Melisa KiyamuTom D. Brutsaert

Abstract

High altitude natives have enlarged vital capacities and residual volumes (RV). Because pulmonary volumes are an indication of functionally relevant traits, such as diffusion capacity, the understanding of the factors (genetic/developmental) that influence lung volumes provides insight into the adaptive responses of highlanders. In order to test for the effect of growth and development at high altitude on lung volumes, we obtained forced vital capacities (FVC), RV, and total lung capacities (TLC) for a sample of 65 Peruvian females of mostly Quechua origins (18-34 years) who were sub-divided into two well-matched groups: 1) sea-level born and raised females (BSL, n = 34) from Lima, Peru (150 m), and 2) high-altitude born and raised females (BHA, n = 31) from Cerro de Pasco, Peru (4,338 m). To determine Quechua origins, Native American ancestry proportion (NAAP) for each individual was assessed using a panel of 70 ancestry informative markers. NAAP was similar between groups (BSL = 91.71%; BHA = 89.93%; P = 0.240), and the analysis confirmed predominantly Quechua origins. After adjusting for body size and NAAP, BHA females had significantly higher FVC (3.79 ± 0.06 l; P < 0.001), RV (0.98 ± 0.03 l; P < 0.001) and TLC (4.80 ± 0.07...Continue Reading

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Citations

Sep 24, 2015·High Altitude Medicine & Biology·Charles A Weitz, Ralph M Garruto
Feb 7, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Charles A WeitzRalph M Garruto
Sep 26, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·A Roberto Frisancho
Nov 12, 2014·American Journal of Physical Anthropology·Melisa KiyamuTom D Brutsaert
May 16, 2015·High Altitude Medicine & Biology·Melisa KiyamuTom D Brutsaert
Aug 9, 2016·Current Opinion in Genetics & Development·Abigail W Bigham
Feb 20, 2019·Genes·Colleen G Julian, Lorna G Moore
Sep 2, 2017·Journal of Applied Physiology·Lorna G Moore
Jul 10, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Xierzhatijiang SulaimanYa-Ping Zhang
Nov 14, 2020·Genome Biology and Evolution·Ainash ChildebayevaAbigail W Bigham
Feb 11, 2021·Genome Biology and Evolution·Ainash ChildebayevaAbigail W Bigham

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