PMID: 11932956Apr 5, 2002Paper

Developmental and hormonal regulation of NR2A mRNA in forebrain regions controlling avian vocal learning

Journal of Neurobiology
J E HeinrichE J Nordeen

Abstract

Developmental changes in the composition of NMDA receptors can alter receptor physiology as well as intracellular signal transduction cascades, potentially shifting thresholds for neural and behavioral plasticity. During song learning in zebra finches, NMDAR currents become faster, and transcripts for the modulatory NR2B subunit of this receptor decrease in lMAN, a region in which NMDAR activation is critical for vocal learning. Using in situ hybridization, we found that NR2A transcripts change reciprocally, increasing significantly in both lMAN (59%) and in another song region, Area X (38%), between posthatch day (PHD) 20 and 40, but not changing further at PHD60 or 80. In adjacent areas not associated with song learning, NR2A mRNA did not change between PHD20-80. Although early song deprivation (which extends the sensitive period for song learning) delays changes in NR2B gene expression and NMDAR physiology within the lMAN, it did not alter NR2A mRNA levels measured at PHD40, 45, or 60. Early testosterone (T) treatment, which disrupts vocal development and accelerates the maturation of both NR2B levels and NMDAR physiology in lMAN, also significantly increased NR2A transcripts measured at PHD35 in lMAN. In Area X, a similar e...Continue Reading

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Citations

Sep 4, 2003·Mental Retardation and Developmental Disabilities Research Reviews·Linda Wilbrecht, Fernando Nottebohm
Jan 1, 1990·Trends in Neurosciences·E J Nordeen, K W Nordeen
Dec 4, 2003·Hormones and Behavior·Heather WilliamsJennifer W Hill
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takae OhnoMasaki Sakurai
Jun 26, 2004·Annual Review of Neuroscience·Thomas R Insel, Russell D Fernald
Aug 18, 2004·Annals of the New York Academy of Sciences·Kathy W Nordeen, Ernest J Nordeen
Aug 18, 2004·Annals of the New York Academy of Sciences·Michael S Brainard
Aug 18, 2004·Annals of the New York Academy of Sciences·David F Clayton
Jun 29, 2012·The Journal of Comparative Neurology·Elena Garcia-Calero, Constance Scharff
Jul 6, 2004·The Journal of Comparative Neurology·Kazuhiro WadaMasatoshi Hagiwara
Jan 30, 2003·Journal of Neurobiology·Tryambak D SinghK W Nordeen
Mar 16, 2007·Journal of Neurophysiology·Noopur AminFrédéric E Theunissen

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