Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide

Endocrinology
V M NavarroM Tena-Sempere

Abstract

The gonadotropic axis is centrally controlled by a complex regulatory network of excitatory and inhibitory signals that is activated at puberty. Recently, loss of function mutations of the gene encoding G protein-coupled receptor 54 (GPR54), the putative receptor for the KiSS-1-derived peptide metastin, have been associated with lack of puberty onset and hypogonadotropic hypogonadism. Yet the pattern of expression and functional role of the KiSS-1/GPR54 system in the rat hypothalamus remain unexplored to date. In the present work, expression analyses of KiSS-1 and GPR54 genes were conducted in different physiological and experimental settings, and the effects of central administration of KiSS-1 peptide on LH release were assessed in vivo. Persistent expression of KiSS-1 and GPR54 mRNAs was detected in rat hypothalamus throughout postnatal development, with maximum expression levels at puberty in both male and female rats. Hypothalamic expression of KiSS-1 and GPR54 genes changed throughout the estrous cycle and was significantly increased after gonadectomy, a rise that was prevented by sex steroid replacement both in males and females. Moreover, hypothalamic expression of the KiSS-1 gene was sensitive to neonatal imprinting by ...Continue Reading

References

Apr 1, 1999·FEBS Letters·D K LeeB F O'Dowd
Apr 3, 2001·The Journal of Steroid Biochemistry and Molecular Biology·L PinillaE Aguilar
Jun 2, 2001·The Journal of Biological Chemistry·A I MuirD C Harrison
Jan 18, 2002·Endocrinology·M Tena-SempereE Aguilar
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Matthew D RingelMotoyasu Saji
Nov 22, 2002·Biology of Reproduction·M L BarreiroM Tena-Sempere
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Yasuko HorikoshiMasahiko Fujino
Jul 9, 2003·Annals of Medicine·Sergio R OjedaAlison Mungenast
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Dec 4, 2003·Biochemical and Biophysical Research Communications·Sandrine FunesEric L Gustafson
Apr 23, 2004·Neuroendocrinology·Manuel Tena-SempereLeonor Pinilla

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Citations

Jul 11, 2006·Diabetologia·A C Hauge-EvansP M Jones
May 16, 2007·Cell and Tissue Research·María GaytánFrancisco Gaytán
Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Sep 28, 2012·Journal of Assisted Reproduction and Genetics·Kulvinder Kochar KaurMandeep Singh
Aug 2, 2011·Journal of Mammary Gland Biology and Neoplasia·Irma H Russo, Jose Russo
Jul 13, 2007·Pituitary·Ericka Barbosa TrarbachAna Claudia Latronico
Jan 9, 2007·Reviews in Endocrine & Metabolic Disorders·Wendy Kuohung, Ursula B Kaiser
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·J T Smith, I J Clarke
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·Felecia Cerrato, Stephanie B Seminara
Mar 7, 2007·Reviews in Endocrine & Metabolic Disorders·Victor M NavarroManuel Tena-Sempere
Mar 24, 2007·Reviews in Endocrine & Metabolic Disorders·Florent G RevelValérie Simonneaux
Mar 23, 2007·Reviews in Endocrine & Metabolic Disorders·Kei-Ichiro MaedaHiroko Tsukamura
Mar 10, 2011·Endocrine·Yathindar S RaoToni R Pak
Nov 10, 2009·Journal of Molecular Neuroscience : MN·Kazuhiro TakahashiKazuhito Totsune
Jul 29, 2010·Journal of Molecular Neuroscience : MN·Ken TakumiHitoshi Ozawa
Mar 26, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhongfa LiuKenneth K Chan
Jul 25, 2009·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Tena-Sempere
Nov 8, 2008·Nature Medicine·Manuel Tena-Sempere
Feb 15, 2008·The New England Journal of Medicine·Milena Gurgel TelesAna Claudia Latronico
Apr 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Junko TomikawaHiroko Tsukamura
Jun 14, 2008·Cerebral Cortex·Susanne NeufangKerstin Konrad
Mar 16, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jill K HineyWilliam Les Dees
Sep 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vinod K SrivastavaWilliam L Dees
Aug 18, 2006·Current Opinion in Pediatrics·Manuel Tena-Sempere
Jul 16, 2008·Current Opinion in Pediatrics·Beth A Kaminski, Mark R Palmert
Nov 9, 2007·Annual Review of Physiology·Simina M PopaRobert A Steiner
Nov 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Annette E CurtisKevin G Murphy
Sep 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Alexander S KauffmanRobert A Steiner
Nov 4, 2010·American Journal of Physiology. Endocrinology and Metabolism·Víctor M NavarroRobert A Steiner
Sep 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·Heather M Dungan LemkoGregory S Fraley
Aug 19, 2007·Neuroendocrinology·X LuanJ Xiao
Sep 28, 2007·Neuroendocrinology·Angelena CrownRobert A Steiner

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