Developmental and reproductive toxicity of soybean isoflavones to immature SD rats

Biomedical and Environmental Sciences : BES
Lei GuanZhen-Yu Chen

Abstract

To investigate the dose-dependent toxic effect of soybean isoflavone extracts (SIE) on reproductive development in immature rats. Growing male and female rats (n = 50 each, 4 weeks) were divided into five groups fed with a standard cereal-based diet and gastrogavaged daily with 0, 30, 150, 300, and 600 mg SIE/kg body weight, respectively, for 12 weeks. Body weight, organ weights, and serum level of estrogen and testosterone were measured. Oral administration of SIE had no effect on food intake but decreased food efficiency ratio (P < 0.01). Suppression on body weight gain by SIE was dose-dependent and the effect was greater on male than on female rats (P < 0.01). SIE at high doses exhibited hepatotoxicity by increasing a relative liver weight, and also caused a smaller uterus but a greater relative ovary in female rats, while leading to larger relative testis and epididymis in male rats. SIE could decrease progesterone concentrations in female rats, whereas in male rats it reduced not only total testosterone level but also sperm count compared with the control group (P < 0.05). SIE at a range of 50-1000 times of human intake level affects not only growth but also development of reproductive system in growing rats.

References

Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·P L WhittenF Naftolin
Aug 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D GalloG Scambia
Apr 28, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M T Velasquez, S J Bhathena
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·L J LuM Nagamani
Dec 4, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K S KangY S Lee
May 31, 2002·Journal of Clinical Pathology·J L Burton, M Wells
Mar 18, 2003·Nutrition Reviews·Ian C MunroHerman Adlercreutz
Jul 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas StrohekerMarie Christine Chagnon
Sep 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Michael G WadeIvan Curran

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Citations

Sep 4, 2009·Biomedical and Environmental Sciences : BES·Wen-Zhong ZhangNing Li
Jun 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y-M ChoA Nishikawa
Feb 6, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Chunqi Wu
Nov 17, 2010·Regulatory Toxicology and Pharmacology : RTP·Jeong-Hwan CheByeong-Cheol Kang
Mar 20, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Anshu YangWei Ma
Jul 28, 2016·Nutritional Neuroscience·Pamelli SilvaPaulo Cezar de Freitas Mathias
Mar 14, 2009·Hormones and Behavior·Rebecca M Calisi, George E Bentley
Jul 24, 2010·Menopause : the Journal of the North American Menopause Society·Adriana Aparecida Ferraz CarbonelJosé Maria Soares
Feb 6, 2017·Oncotarget·Xiang TongHong Fan
Jul 6, 2019·Critical Reviews in Food Science and Nutrition·Chengshen HuWing-Fu Lai
Jan 10, 2020·Journal of Animal Physiology and Animal Nutrition·Sameh A AbdelnourAyman A Swelum
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Amanda Alves LoziReggiani Vilela Gonçalves
Jan 16, 2013·Journal of Agricultural and Food Chemistry·Jianping LiZaibin Hao

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