PMID: 9421140Jan 8, 1998Paper

Developmental and sensory-dependent changes of phosphoinositide-linked metabotropic glutamate receptors

The Journal of Comparative Neurology
S N ReidN W Daw

Abstract

Metabotropic glutamate receptors (mGluRs) can modulate synaptic transmission, and there is evidence that phosphoinositide (PI)-linked mGluRs may be involved in sensory-dependent plasticity during the development of cat visual cortex. Consequently, we asked the questions: Where are the PI-linked mGluRs (mGluR1alpha and mGluR5) in the visual cortex? Does the quantity and distribution of these receptors change in the cat visual cortex during postnatal development, and are these features sensory-dependent? We found that the quantity of mGluR1alpha decreases with age, whereas the laminar distribution of mGluR1alpha remains the same. Quantity of mGluR5 also decreases, but the laminar distribution of mGluR5 changes during development. The pattern and timing of the mGluR5 change in distribution follow the development of geniculocortical afferents. Immunostaining indicates that reduction of receptor occurs mainly in layers V-VI for mGluR1alpha and outside layer IV for mGluR5. Dark-rearing postpones the laminar change of mGluR5 and produces an increased level of mGluR5 between postnatal 1.5-6 weeks of age but has no significant effect on the mGluR1alpha distribution or the mGluR1alpha quantity. These results suggest that mGluR1alpha and ...Continue Reading

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Citations

Nov 28, 2006·Biological Psychiatry·Purificación Tejedor-RealJacques Mallet
Sep 9, 2006·CNS Drug Reviews·Paul M Lea, Alan I Faden
Jul 1, 2004·Journal of Child Neurology·Timothy A SimeoneJong M Rho
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·P M Lea, A I Faden
Jun 24, 2004·Journal of Neurophysiology·Yan Rao, Nigel W Daw
Oct 6, 2007·Molecular Neurobiology·Maria Vincenza CataniaFerdinando Nicoletti
Aug 13, 2009·Experimental Brain Research·Marian Tsanov, Denise Manahan-Vaughan
Dec 16, 2000·The Journal of Comparative Neurology·S N Reid, C Romano
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C F HohmannM E Blue
Jun 22, 2006·Epilepsy Research·Georgia M Alexander, Dwayne W Godwin

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