Developmental and spatial expression pattern of alpha-taxilin in the rat central nervous system

The Journal of Comparative Neurology
Shin-ichi SakakibaraShuichi Ueda

Abstract

Alpha-taxilin has been identified as a binding partner of syntaxin family members and thus has been proposed to function in syntaxin-mediated intracellular vesicle trafficking. However, the lack of detailed information concerning the cellular and subcellular localization of alpha-taxilin impedes an understanding of the role of this protein. In the present study, we characterized alpha-taxilin-expressing cells in the rat CNS with a specific antibody. During embryonic development, alpha-taxilin was prominently expressed in nestin-positive neural stem cells in vivo and in vitro. As CNS development proceeded, the alpha-taxilin expression level was rapidly down-regulated. In the postnatal CNS, alpha-taxilin expression was almost confined to the neuronal lineage, with the highest levels of expression in motor neurons within the brainstem nuclei and spinal cord and in primary sensory neurons in mesencephalic trigeminal nucleus. At the cellular level, alpha-taxilin was preferentially located in Nissl substance-like structures with a tigroid or globular morphology within the soma and proximal to dendrites, but it was excluded from terminals. Combined staining with propidium iodide demonstrated that alpha-taxilin distribution overlapped ...Continue Reading

References

Dec 1, 1990·Trends in Biochemical Sciences·H R Pelham
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M NishizawaS Kawai
May 1, 1988·The Journal of Comparative Neurology·R P TuckerA I Matus
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 24, 1983·Nature·I G Haas, M Wabl
Feb 1, 1994·Journal of Neurobiology·M F MarusichJ A Weston
Sep 10, 1993·Cell·M K BennettR H Scheller
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S K SappersteinM G Waters
Apr 1, 1996·Trends in Neurosciences·A H Futerman, G A Banker
Feb 12, 1998·The Journal of Cell Biology·M H LauberG Jürgens
Nov 17, 1998·The Journal of Cell Biology·R PrekerisR H Scheller
Aug 6, 1999·Molecular Biology of the Cell·S D Conner, G M Wessel
Sep 8, 2001·Cell and Tissue Research·R Hepp, K Langley
Aug 13, 2002·Cell and Tissue Research·J-C Floyd SarriaHarald Hirling
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shin-ichi SakakibaraHideyuki Okano
Dec 12, 2002·Cellular and Molecular Life Sciences : CMLS·S RospertM Gautschi
Feb 1, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Satoru NogamiHiromichi Shirataki
Nov 19, 2003·Biochemical and Biophysical Research Communications·Satoru NogamiHiromichi Shirataki
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alessia PascaleAlessandro Quattrone
Jun 9, 2004·Biochemical and Biophysical Research Communications·Satoru NogamiHiromichi Shirataki
Jun 26, 2004·Annual Review of Neuroscience·Thomas C Sudhof
Jul 9, 2004·Developmental Cell·Arie Koen BraatPaul M Macdonald
Apr 20, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kenji YoshidaHiromichi Shirataki
May 17, 2005·Biochimica Et Biophysica Acta·Wanjin Hong
Aug 9, 2005·Brain Research. Molecular Brain Research·Sueli M Oba-ShinjoMari C Sogayar
Jun 21, 2006·Journal of Neuroscience Research·Masatomo WatanabeKouichi Itoh
Aug 17, 2006·Nature Reviews. Molecular Cell Biology·Reinhard Jahn, Richard H Scheller
Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Sep 13, 2007·Nature Reviews. Neuroscience·Clive R Bramham, David G Wells

❮ Previous
Next ❯

Citations

Aug 3, 2012·Journal of Neurophysiology·James R AustgenDavid D Kline
Oct 5, 2013·Histochemistry and Cell Biology·Yukimi HoriiHiromichi Shirataki
Dec 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jinghui ZhaoAlfred Lewis Goldberg
Jan 11, 2017·Glia·Giorgia FattoriniFiorenzo Conti
Jul 14, 2018·The Journal of Comparative Neurology·Seiya Yamada, Shin-Ichi Sakakibara
Oct 15, 2009·Nature Reviews. Neuroscience·Allan R JonesSusan M Sunkin
Mar 19, 2020·BioMed Research International·Shuangyu LvXiangqian Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Satoru NogamiHiromichi Shirataki
Biochemical and Biophysical Research Communications
Satoru NogamiHiromichi Shirataki
Biochemical and Biophysical Research Communications
Satoru NogamiHiromichi Shirataki
© 2022 Meta ULC. All rights reserved