PMID: 11902323Mar 21, 2002Paper

Developmental assessment-based surgical intervention for intractable epilepsies in infants and young children

Epilepsia
T MatsuzakaC Kawasaki

Abstract

To define the most appropriate time for surgery for medically intractable epilepsies in infants and young children. First we examined retrospectively the changes in developmental quotients (DQs) during the clinical course and the clinical factors affecting the DQ in 39 consecutive patients younger than 15 years, who underwent surgical treatment for intractable epilepsy. Second, we examined prospectively five new patients for early detection of developmental arrest or regression by periodic developmental assessments and whether this could lead to early surgical intervention, eventually resulting in minimal developmental defects. Retrospective studies revealed that the DQ progressively decreased with age and that the reduction of DQ was related to continuing frequent seizures in many patients. The prospective studies demonstrated that periodic developmental assessments could detect the reduction of DQ at 5 months or later after onset of frequent seizures in three patients. In two other patients, operations were performed before reduction of DQs, and their postoperative DQ levels were normal. The post-operative recovery of DQ was complete in one patient whose operation was performed 3 months after reduction of DQ, whereas it was i...Continue Reading

Citations

Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Carolyn E PizoliMatthew D Smyth
Apr 8, 2015·Epilepsy & Behavior : E&B·Georges A Ghacibeh, Cheryl Fields
Feb 26, 2013·Brain & Development·Monique M J Van Schooneveld, Kees P J Braun
Feb 18, 2012·Brain & Development·Yoshiko IwataniKeiichi Ozono
May 3, 2011·Epilepsy & Behavior : E&B·Mustafa SahinRaj D Sheth
Mar 17, 2006·Epilepsy & Behavior : E&B·Gregory L Holmes, Pierre-Pascal Lenck-Santini
Jun 1, 2012·Epilepsy Research·Yoshiko IwataniKeiichi Ozono
May 11, 2010·Neurobiology of Disease·Omar I KhanGregory L Holmes
Jul 2, 2008·Journal of Neurosurgery. Pediatrics·Kyu-Won ShimDong-Seok Kim

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