Developmental cell interactions of Myxococcus xanthus: analysis of mutants.

Journal of Bacteriology
R LaRossaD Kaiser

Abstract

A set of developmental mutants have been examined that behave as if defective in cellular interactions necessary for the formation of myxospores during fruiting body development. Sporulation is rescued in these mutants if they are mixed with wild-type cells. Complementation experiments with whole cells divide the mutants into four groups (A, B, C, and D). Mutants of group A appear to be less responsive to starvation, a condition that normally initiates development. Mutants of group D respond to starvation but fail to synthesize myxobacterial hemagglutinin, a protein normally synthesized midway in development. Mutants of groups B and C respond to starvation and synthesize hemagglutinin, but they can be distinguished genetically. Group C mutations all map in a single cluster near insertion omega 1519 of transposon Tn5, which is distant from group B mutations. Thus, each group represents a different defect in development. All of the mutants are induced to sporulate by glycerol. Therefore, we argue that sporulation during fruiting body development depends on several prior interactions between cells.

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Citations

Jul 11, 2006·Annual Review of Microbiology·Dale Kaiser
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Peter MeiserRolf Müller
Jan 1, 1987·Critical Reviews in Microbiology·L J Shimkets
Jan 1, 1986·Critical Reviews in Microbiology·K Stephens
Nov 5, 1999·Annual Review of Microbiology·L J Shimkets
Feb 18, 2006·Journal of Bacteriology·Michelle E DiodatiAnthony G Garza
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·I M Keseler, D Kaiser
Oct 19, 2004·Annual Review of Microbiology·Dale Kaiser
Dec 11, 2003·Eukaryotic Cell·Xiaorong LinMichelle Momany
Nov 14, 2000·Journal of Bacteriology·A G GarzaM Singer
Sep 7, 2001·Annual Review of Microbiology·M B Miller, B L Bassler
Oct 9, 1999·Journal of Bacteriology·K A O'Connor, D R Zusman
Nov 13, 1998·Journal of Bacteriology·L Gorski, D Kaiser
Oct 29, 2018·Protoplasma·Karl J NiklasStuart A Newman
Aug 29, 1998·Journal of Bacteriology·A G GarzaM Singer
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May 1, 1989·Journal of Bacteriology·A Kuspa, D Kaiser
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Nov 1, 1988·Journal of Bacteriology·R E Gill, M C Bornemann
Dec 1, 1984·Journal of Bacteriology·M VaronE Rosenberg

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