Developmental changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor properties and expression in the rat hippocampal formation

Neuroscience
S. StandleyM. Baudry

Abstract

The developmental changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor properties in rat hippocampus were evaluated with quantitative autoradiography of ligand binding and in situ hybridization performed in adjacent sections with antisense oligonucleotides for AMPA receptor subunits (GluR1-3, flip and flop splice variants). Specific 3H-AMPA binding in different hippocampal subfields increased between postnatal day 7 and 15 and was higher in CA3 during the postnatal period when compared to adult levels. This effect was mostly due to high levels of high affinity binding sites in cell body layers during the developmental period. By contrast, autoradiograms of 3H-AMPA binding predominantly to the low affinity binding sites indicated an absence of these sites in cell body layers and the overall levels of binding exhibited little overshoot compared to adult levels during the developmental period. The changes in binding of the antagonist of the AMPA receptor, 6-nitro-7-cyanoquinoxaline-2,3-dione were markedly different from those for the high affinity AMPA binding sites but quite similar to those for the low affinity sites. The binding was extremely low at postnatal day 7 and increased rapidly between postn...Continue Reading

References

Sep 14, 1992·Neuroscience Letters·D E Pellegrini-GiampietroR S Zukin
Apr 15, 1992·The Journal of Comparative Neurology·R S Petralia, R J Wenthold
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroW A Pulsinelli
Feb 17, 1992·Neuroscience Letters·S S SchreiberM Baudry
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroR S Zukin
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S L Erdö, J R Wolff
Aug 3, 1990·Science·K KeinänenP H Seeburg
Jan 1, 1989·Neuropsychologia·T J TeylerK M Harris
Feb 3, 1987·Brain Research·R W OlsenC R Houser
Jan 1, 1987·Progress in Neurobiology·M L Mayer, G L Westbrook
Jun 8, 1984·Science·G Lynch, M Baudry
Sep 21, 1984·Science·J P ChangeuxP Chemouilli
Jan 1, 1980·Anatomy and Embryology·R Loy

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Citations

Oct 24, 2000·The Journal of Comparative Neurology·J E TurmanS H Chandler
Jul 14, 1997·Journal of the Autonomic Nervous System·H RaoJ P Kessler
Jun 24, 1998·Brain Research. Developmental Brain Research·S StandleyM Baudry
Nov 5, 1997·Trends in Neurosciences·D E Pellegrini-GiampietroR S Zukin
Oct 31, 1998·Brain Research. Molecular Brain Research·L K Friedman, J Velísková
Apr 9, 2001·Environmental Toxicology and Pharmacology·H -H. ChenI K. Ho
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A M BrambrinkR J Traystman
Jul 22, 1999·Annals of the New York Academy of Sciences·S M PradhanC E Niesen
Jul 22, 1999·Annals of the New York Academy of Sciences·L K Friedman, A Velísková
Nov 24, 2012·Brain Research Bulletin·Katalin Czöndör, Olivier Thoumine
Jun 16, 2004·Neuroscience Letters·Keiji OguroKuniko Shimazaki
Sep 10, 2016·Neuropsychological Rehabilitation·Anne AdeltNicole Stadie
Jan 11, 2020·Frontiers in Neuroanatomy·Sabrina BehuetKatrin Amunts
Aug 7, 2003·Journal of Neuropathology and Experimental Neurology·Linda K FriedmanHongguang Liu
Dec 18, 2013·Physiological Research·E Szczurowska, P Mareš

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