Developmental changes in catecholamine requirement, volume load and corticosteroid supplementation in premature infants born at 22 to 28 weeks of gestation

Early Human Development
Kaori MichikataTsuyomu Ikenoue

Abstract

Due to circulatory instability, premature infants require volume loads, catecholamines and steroid supplementation to improve mortality and neurodevelopmental outcome. However, a complete quantitative analysis concerning the relationship between supplementation and gestational age, especially in infants born at 22 to 24 weeks of gestation, is lacking. To investigate whether less mature infants need higher doses of catecholamine, volume loads and steroid, and whether those who require higher doses have poorer outcome. A retrospective, observational study was performed at a tertiary center in a university setting. Among the consecutive 221 premature infants born at 22 to 28 weeks of gestation, we selected 108 infants who had no apparent pathological conditions other than prematurity. Catecholamines, volume loads and steroid, given to attain sufficient blood pressure and urinary output, were quantitatively analyzed during the first 24 hours. Quantity of catecholamines, volume expanders and steroid supplementation as a function of gestational age and childhood outcome at 2 years. Catecholamines and volume loads were increased in a step-wise manner with decreasing gestational age. Intact survival rate was significantly lower in infa...Continue Reading

References

Dec 1, 1978·The Journal of Physiology·C T Jones, J W Ritchie
Aug 1, 1983·American Journal of Obstetrics and Gynecology·M Phillippe
Sep 1, 1980·Clinical Obstetrics and Gynecology·R Artal
Jul 1, 1993·Archives of Disease in Childhood·J C RozéA Mouzard
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Kluckow, N Evans
Feb 13, 2001·Seminars in Neonatology : SN·I Seri
Apr 3, 2001·Early Human Development·W D Engle
Feb 28, 2002·The Journal of Pediatrics·David OsbornMartin Kluckow
Feb 11, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hiroshi SameshimaTsuyomu Ikenoue

❮ Previous
Next ❯

Citations

Jan 28, 2014·Early Human Development·Seishi FurukawaTsuyomu Ikenoue
Jul 8, 2014·Early Human Development·Ken FurutaHiroshi Sameshima
May 29, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Kaori MichikataKazuhiko Nakame

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.