Developmental Changes in Electrophysiological Properties and a Transition from Electrical to Chemical Coupling between Excitatory Layer 4 Neurons in the Rat Barrel Cortex

Frontiers in Neural Circuits
Fliza ValiullinaAndrei Rozov

Abstract

During development, sensory systems switch from an immature to an adult mode of function along with the emergence of the active cortical states. Here, we used patch-clamp recordings from neocortical slices in vitro to characterize the developmental changes in the basic electrophysiological properties of excitatory L4 neurons and their connectivity before and after the developmental switch, which occurs in the rat barrel cortex in vivo at postnatal day P8. Prior to the switch, L4 neurons had higher resting membrane potentials, higher input resistance, lower membrane capacity, as well as action potentials (APs) with smaller amplitudes, longer durations and higher AP thresholds compared to the neurons after the switch. A sustained firing pattern also emerged around the switch. Dual patch-clamp recordings from L4 neurons revealed that recurrent connections between L4 excitatory cells do not exist before and develop rapidly across the switch. In contrast, electrical coupling between these neurons waned around the switch. We suggest that maturation of electrophysiological features, particularly acquisition of a sustained firing pattern, and a transition from the immature electrical to mature chemical synaptic coupling between excitat...Continue Reading

References

Jul 31, 1992·Science·R YusteL C Katz
Nov 1, 1990·Brain Research. Developmental Brain Research·R S Erzurumlu, S Jhaveri
Feb 1, 1997·Neuron·J T IsaacR C Malenka
Feb 11, 1998·The Journal of Physiology·G StuartB Sakmann
Jun 8, 1999·The Journal of Physiology·D FrickerR Miles
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·L VenanceH Monyer
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
May 24, 2003·Cerebral Cortex·Zoltán MolnárGuillermina López-Bendito
May 23, 2006·Trends in Neurosciences·Rustem Khazipov, Heiko J Luhmann
Jun 17, 2006·Science·Randy M Bruno, Bert Sakmann
Sep 5, 2006·Cerebral Cortex·Mathieu MilhRustem Khazipov
Nov 10, 2006·Journal of Neurophysiology·Marat MinlebaevRustem Khazipov
Oct 30, 2007·Neuron·Carl C H Petersen
Jul 30, 2008·Cerebral Cortex·Marat MinlebaevRoustem Khazipov
Jul 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenq-Wei YangHeiko J Luhmann
Dec 3, 2009·Nature Reviews. Neuroscience·Aaron G Blankenship, Marla B Feller
Jun 1, 2010·Neurophysiologie clinique = Clinical neurophysiology·M AndréP Plouin
Aug 11, 2010·Neuron·Matthew T ColonneseRustem Khazipov
Oct 15, 2011·Science·Marat MinlebaevRoustem Khazipov
Mar 6, 2012·NeuroImage·Matthew Colonnese, Rustem Khazipov
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas Narboux-NêmePatricia Gaspar
May 23, 2012·The European Journal of Neuroscience·Reha S Erzurumlu, Patricia Gaspar
Jul 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuming AnHeiko J Luhmann
Jul 17, 2012·Frontiers in Neuroanatomy·Dirk Feldmeyer
Oct 23, 2012·Current Biology : CB·Alexandre TiriacMark S Blumberg
Dec 1, 2012·Progress in Neurobiology·Dirk FeldmeyerCornelius Schwarz
Jul 23, 2013·Neuroscience·R KhazipovG Valeeva
Mar 13, 2014·Cerebral Cortex·Alex Crocker-BuqueMichael I Daw

❮ Previous
Next ❯

Citations

Jan 10, 2018·Frontiers in Cellular Neuroscience·Mikhail SintsovMarat Minlebaev
Jan 13, 2018·Frontiers in Cellular Neuroscience·Elvira JuzekaevaRoustem Khazipov
Oct 6, 2017·Frontiers in Cellular Neuroscience·Matthew T ColonneseYasunobu Murata
Feb 5, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lorena SaavedraDaniel Haag
May 2, 2018·Current Opinion in Neurobiology·Matthew T Colonnese, Marnie A Phillips
Jul 23, 2021·Neuron·Francisco J MartiniGuillermina López-Bendito

❮ Previous
Next ❯

Software Mentioned

Origin
MATLAB
pClamp
PatchMaster

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
F M Zhou, J J Hablitz
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sarah J Etherington, Stephen R Williams
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Lang WangArianna Maffei
© 2021 Meta ULC. All rights reserved