PMID: 8941523Nov 1, 1996Paper

Developmental changes in endothelium-dependent relaxation of pulmonary arteries: role of EDNO and prostanoids

Journal of Applied Physiology
D C O'DonnellJ B Gordon

Abstract

We hypothesized that maturational changes in both prostaglandin and endothelium-derived nitric oxide (EDNO) activity contribute to developmental changes in endothelium-dependent relaxation of newborn pulmonary arteries. Responses to endothelium-dependent vasodilators acetylcholine, bradykinin, and calcium ionophore A-23187 were determined in phenylephrine-constricted third- and fourth-generation (1- to 2-mm-diameter) pulmonary artery rings from 2-day (2d)- and 1-mo (1m)-old lambs under control conditions (Con), after inhibition of EDNO synthesis with N omega-nitro-L-arginine (L-NNA), after inhibition of prostanoid synthesis with meclofenamate (Mec), or both modulators with both inhibitors. Endothelium-independent responses to sodium nitroprusside (SNP) were also measured in Con rings. Endothelium-dependent relaxation was greater in 2d than 1m Con rings, particularly at high concentrations when an increase in tension occurred in 1m rings. L-NNA attenuated endothelium-dependent relaxation more in 2d rings, and SNP caused greater relaxation in 2d rings. However, Mec abolished all age-related differences by attenuating relaxation in 2d rings and constriction in 1m rings. These data suggest that developmental changes in endothelium-...Continue Reading

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Citations

Sep 28, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura MorenoFrancisco Perez-Vizcaino
Jan 13, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judy L AschnerCandice D Fike
Jul 14, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthew A Boegehold
Mar 7, 2012·Journal of Receptor and Signal Transduction Research·Lei YuDaling Zhu
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·T R HallaJ B Gordon
Nov 22, 2001·Journal of Applied Physiology·B J CanningS B Mazzone
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judy L AschnerMamta Fuloria

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