Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats

Brain Research. Developmental Brain Research
D Becú-VillalobosC Libertun

Abstract

Follicle-stimulating hormone (FSH) secretion is increased in the immature female rat from day 5 to days 17-18 of life, and decreases steadily thereafter until puberty. It has been reported that estradiol negative feedback and inhibin-like peptides are low during this period, while luteinizing hormone (LH) and FSH sensitivity to LH-releasing hormone (LHRH) are maximal. It was therefore of interest to study the effects of some neurotropic drugs on FSH release at 12 days of age, and to compare their effects at 1 and 20 days. Besides, as developmental patterns and regulation of FSH are different in male and female rats, the experiments were carried out using male and female littermates. The drugs chosen were haloperidol, 5-hydroxytryptophan and naloxone. These drugs release LH in the infantile female rat, the effect decreasing or disappearing as the animal matures; no effects of these drugs have been reported on FSH release in infantile rats to the present time. It was found that haloperidol (0.25 mg/kg), naloxone (2 mg/kg) and 5-hydroxytryptophan (50 mg/kg) markedly increased the already high titers of FSH in the 12-day-old female rat. This effect could not be discerned in newborn rats, and had disappeared at 20 days of age. Male ...Continue Reading

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Citations

Dec 1, 1990·Cellular and Molecular Neurobiology·D Becú-VillalobosC Libertun
Feb 1, 1995·Cellular and Molecular Neurobiology·D Becú-Villalobos, C Libertun
Nov 20, 1992·Brain Research. Developmental Brain Research·G Díaz-TorgaC Libertun
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·G T Shishkina, N N Dygalo
Jun 1, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·M A AragónR Domínguez

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