Developmental changes in glucose transport of guinea pig erythrocytes

The Journal of Clinical Investigation
T Kondo, E Beutler

Abstract

The developmental changes in the capacity for D-glucose transport of guinea pig erythrocyte membranes were compared to alterations in the electrophoretic pattern of erythrocyte membrane components. Guinea pig erythrocytes lose their D-glucose carrier functions during development. Good correlation was observed between the loss of glucose uptake and apparent decrease of the zone 4.5 of Coomassie Blue-stained membrane proteins on electrophoresis. Reconstitution of membrane preparations in liposomes resulted in a parallel change in the D-glucose uptake and D-glucose penetration of intact erythrocytes. This suggests that the decrease of D-glucose transport capacity during development is caused by the loss of one or more protein components from the erythrocyte membranes.

References

Jul 1, 1974·The Journal of Cell Biology·T L Steck
May 1, 1973·Analytical Biochemistry·P W Holloway
Apr 1, 1958·Journal of Cellular Physiology·P C LARIS
Jan 1, 1963·Archives of Biochemistry and Biophysics·J T DODGED J HANAHAN

Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·R L IngermannJ M Bissonnette
Nov 1, 1987·Placenta·R L Ingermann
Jan 1, 1983·Acta Neurologica Scandinavica·A Gjedde
Aug 1, 1981·Journal of Neurochemistry·R M CawthonX O Breakefield
May 1, 1986·Journal of Neurochemistry·A FuglsangA Gjedde

Related Concepts

Blood Glucose
Carrier Proteins
SDS-PAGE
Red Cell Ghost
Erythrocytes
Cavia porcellus
Niosomes
Cell Surface Proteins

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