Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
E C CottrellS E Ozanne

Abstract

In the adult brain, leptin regulates energy homeostasis primarily via hypothalamic circuitry that affects food intake and energy expenditure. Evidence from rodent models has demonstrated that during early postnatal life, leptin is relatively ineffective in modulating these pathways, despite the high circulating levels and the presence of leptin receptors within the central nervous system. Furthermore, in recent years, a neurotrophic role for leptin in the establishment of energy balance circuits has emerged. The precise way in which leptin exerts these effects, and the site of leptin action, is unclear. To provide a detailed description of the development of energy balance systems in the postnatal rat in relation to leptin concentrations during this time, endogenous leptin levels were measured, along with gene expression of leptin receptors and energy balance neuropeptides in the medial basal hypothalamus, using in situ hybridization. Expression of leptin receptors and both orexigenic and anorexigenic neuropeptides increased in the arcuate nucleus during the early postnatal period. At postnatal day 4 (P4), we detected dense leptin receptor expression in ependymal cells of the third ventricle (3V), which showed a dramatic reduct...Continue Reading

References

Mar 1, 1978·The American Journal of Anatomy·R J WalshP L Lin
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F De VitryA Tixier-Vidal
Jul 1, 1997·The American Journal of Physiology·D V RaynerP Trayhurn
Sep 23, 1997·Biochemical and Biophysical Research Communications·S U DevaskarP A Rajakumar
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P TrayhurnD V Rayner
Sep 14, 1999·The American Journal of Physiology·A M MistryD R Romsos
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J G MercerP J Morgan
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Jun 9, 2000·Annual Review of Physiology·R S Ahima, J S Flier
Dec 12, 2001·Molecular and Cellular Endocrinology·B MorashM Wilkinson
Mar 12, 2002·The European Journal of Neuroscience·Kanishka N NilaweeraPeter J Morgan
Nov 15, 2003·Molecular and Cellular Endocrinology·Barbara A MorashMichael Wilkinson
Dec 6, 2003·The Journal of Endocrinology·K-H LinC-S Wang
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastien G BouretRichard B Simerly
Mar 27, 2004·Endocrinology·Sebastien G Bouret, Richard B Simerly
Apr 6, 2004·Science·Sebastien G BouretRichard B Simerly
Nov 12, 2005·Endocrinology·Jun UdagawaHiroki Otani
Jan 24, 2007·Nature Reviews. Neuroscience·H Troy GhashghaeiE S Anton
Jan 25, 2007·Journal of Neuroscience Research·Claire-Dominique WalkerDenis Richard
Mar 30, 2007·Journal of Chemical Neuroanatomy·Anne-Sophie CarloLynda M Williams
Jul 11, 2007·Journal of Neuroendocrinology·S G Bouret, R B Simerly
Aug 11, 2007·Congenital Anomalies·Jun UdagawaHiroki Otani
Sep 18, 2007·Endocrinology·A-S CarloW Meyerhof
Dec 25, 2007·Physiology & Behavior·E C Cottrell, S E Ozanne
May 20, 2008·Brain Research·Andrea FrontiniAntonio Giordano

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Citations

Dec 25, 2012·Journal of Neural Transmission·Paige BeckEdgar Garcia-Rill
Dec 29, 2011·The Journal of Clinical Investigation·David E G McNayJeffrey S Flier
Feb 10, 2012·PloS One·Leona PlumDomenico Accili
Apr 17, 2015·Journal of Molecular Endocrinology·Matei BolboreaPerry Barrett
Apr 11, 2015·Frontiers in Endocrinology·Pilar Argente-ArizónJulie A Chowen
Jul 25, 2015·Frontiers in Neuroendocrinology·Lori M Zeltser
Apr 2, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Takeshi IwasaMinoru Irahara
Apr 30, 2017·The Journal of Endocrinology·Luba SominskySarah J Spencer
Mar 17, 2018·The Journal of Endocrinology·Luba SominskySarah J Spencer
Apr 18, 2018·Nature Reviews. Neuroscience·Lori M Zeltser
Mar 22, 2012·Obesity Facts·Miriam GranadoJulie A Chowen
Nov 11, 2017·Frontiers in Endocrinology·Ilvana ZikoSarah J Spencer
Feb 8, 2018·Frontiers in Neuroanatomy·Xuefeng YuanLaurent Gautron
Jun 23, 2018·The Journal of Endocrinology·Melody L Allensworth-JamesGwen Childs
Dec 18, 2009·The Journal of Comparative Neurology·Emilie CaronSebastien G Bouret
Sep 25, 2018·Autism Research : Official Journal of the International Society for Autism Research·Ramkripa RaghavanXiaobin Wang
Nov 4, 2010·European Journal of Applied Physiology·Ya-Wen HsuPaulus S Wang
Mar 6, 2012·Journal of Neuroscience Research·Bo-Chul ShinSherin U Devaskar
May 23, 2013·Journal of Neurochemistry·Paige BeckEdgar Garcia-Rill
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Margaret J Morris
Apr 4, 2019·Frontiers in Neuroscience·Sooyeon YooSeth Blackshaw
Oct 2, 2019·Frontiers in Neuroscience·Inga Bae-GartzEva Hucklenbruch-Rother
Jan 31, 2020·Frontiers in Endocrinology·Jayme van DalumDavid G Hazlerigg
Oct 2, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Claudia G LiberiniMatthew R Hayes
Sep 25, 2012·Current Cardiovascular Risk Reports·Jwan Rkhzay-JafClaire J Stocker
Aug 9, 2020·Current Diabetes Reports·Ankur RughaniJeanie B Tryggestad
Dec 18, 2014·American Journal of Physiology. Endocrinology and Metabolism·Jessica F BriffaDeanne H Hryciw
Nov 13, 2012·Clinical Genetics·C Schuurmans, D M Kurrasch
Sep 4, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Alicja A SkowronskiCharles A LeDuc

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