Developmental changes in intercellular junctions and Kv channels in the intestine of piglets during the suckling and post-weaning periods

Journal of Animal Science and Biotechnology
Jing WangYulong Yin

Abstract

The intestinal epithelium is an important barrier that depends on a complex mixture of proteins and these proteins comprise different intercellular junctions. The purpose of this study was to investigate the postnatal and developmental changes in morphology, intercellular junctions and voltage-gated potassium (Kv) channels in the intestine of piglets during the suckling and post-weaning periods. Samples of the small intestine were obtained from 1-, 7-, 14-, and 21-d-old suckling piglets and piglets on d 1, 3, 5, and 7 after weaning at 14 d of age. The results showed that the percentage of proliferating cell nuclear antigen (PCNA)-positive cells and alkaline phosphatase (AKP) activity, as well as the abundances of E-cadherin, occludin, and Kv1.5 mRNA and claudin-1, claudin-3, and occludin protein in the jejunum were increased from d 1 to d 21 during the suckling period (P < 0.05). Weaning induced decreases in the percentage of PCNA-positive cells, AKP activity and the abundances of E-cadherin, occludin and zonula occludens (ZO)-1 mRNA or protein in the jejunum on d 1, 3 and 5 post-weaning (P < 0.05). There were lower abundances of E-cadherin, occludin and ZO-1 mRNA as well as claudin-1, claudin-3 and ZO-1 protein in the jejunum ...Continue Reading

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Citations

Oct 9, 2018·Microscopy Research and Technique·Tomasz H Skrzypek, Waldemar Kazimierczak
Jul 28, 2019·Journal of Animal Physiology and Animal Nutrition·Zirui ZhouYulong Yin
Aug 14, 2019·Animal : an International Journal of Animal Bioscience·F J JiY L Yin
Mar 9, 2019·Frontiers in Veterinary Science·Xia XiongYanhong Liu
Sep 7, 2017·Journal of Pineal Research·Wenkai RenYulong Yin
Feb 2, 2021·Physiological Reports·Brodie DelucoHeather L Wilson

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Methods Mentioned

BETA
Assay
scanning electron microscopy
electrophoresis
PCR

Software Mentioned

Pro Plus
SPSS
Image

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