Developmental changes in ionic channel activity in the embryonic murine heart

Circulation Research
M P DaviesR S Kass

Abstract

We have isolated murine embryonic atrial and ventricular cells derived from timed-pregnant females at different periods and used patch-clamp procedures to investigate age- and chamber-specific expression of ionic channels in the developing fetal mouse. Our data indicate that L-type Ca2+ channels play a dominant role in excitation during early murine cardiac embryogenesis and that Na+ channel expression increases dramatically just before birth. K+ channel expression is particularly sensitive to changes during development. Neither atrial nor ventricular cells express a slowly activating component of delayed rectification (IKs) until just before birth, and inwardly rectifying channel activity, associated with determination of cellular resting potential, is not markedly apparent until late stages of embryogenesis. Instead, we find robust expression of the ATP-regulated K+ channel at early and late states of embryonic development, which may indicate a novel functional role for this channel during morphogenesis of the heart. These results have important implications for the physiology and development of the murine cardiac conduction system and will also serve as a baseline for future studies designed to investigate developmental chan...Continue Reading

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L Roberds, M M Tamkun
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M PaulmichlD E Clapham
Apr 9, 1990·Biochimica Et Biophysica Acta·I R Josephson, N Sperelakis
May 1, 1985·Pflügers Archiv : European journal of physiology·K BenndorfB Nilius
Mar 1, 1988·The Journal of Membrane Biology·S FujiiR L DeHaan
Aug 1, 1988·The Journal of General Physiology·R Horn, A Marty
Aug 1, 1983·Canadian Journal of Physiology and Pharmacology·S Virágh, C E Challice
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·E DysonK R Chien
Sep 1, 1994·The Journal of Physiology·H B Nuss, E Marban
Sep 1, 1994·The American Journal of Physiology·A FelipeM M Tamkun
Aug 11, 1994·Nature·M L AshfordJ P Adelman
Oct 1, 1993·Hypertension·J J Mullins, L J Mullins
Jan 1, 1993·Annual Review of Physiology·L J Field

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Citations

Jun 12, 2002·Journal of Molecular and Cellular Cardiology·Laurent FerronJean-François Renaud
Sep 26, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·V A LettsW N Frankel
Jan 23, 2013·Pflügers Archiv : European journal of physiology·Jie DingJörg W Wegener
Nov 13, 2008·Systems and Synthetic Biology·Hitomi ItohMasaru Tomita
May 24, 2005·Reproductive Toxicology·Bengt A J KällénBengt R Danielsson
Oct 2, 2001·Archives of Medical Research·C Orozco-BuenrostroC M Torres
Sep 11, 2002·Reproductive Toxicology·Anna-Carin SköldBengt R Danielsson
Sep 2, 2003·Epilepsy Research·Bengt R DanielssonTorbjörn Tomson
Jul 25, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·A GünlemezA S Gökalp
Jul 10, 2013·Nature Medicine·Russell C Addis, Jonathan A Epstein
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·J J Zwaginga, P Doevendans
May 30, 2002·Journal of Anatomy·C MummeryM Pera
Jan 8, 2008·Cardiovascular Research·Jorge N DomínguezAmelia E Aránega
Mar 24, 2011·Cardiovascular Research·Diego FrancoAmelia Aránega
Jun 4, 1999·Journal of Cardiovascular Electrophysiology·L ChenM Boutjdir
May 19, 1998·Pharmacology & Toxicology·I W Smoak, A N Emanuel
Mar 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Einsley JanowskiMartin Morad
Mar 27, 2010·Circulation Research·Sameer S ChopraDan M Roden
Dec 17, 2009·Circulation·Huei-Sheng Vincent ChenMark Mercola
Dec 20, 2000·The Journal of Clinical Investigation·M P LeeA P Feinberg
Aug 30, 2012·Biomedical Engineering Online·Michelangelo PaciStefano Severi
Aug 9, 2005·Pediatric Research·Alison MorrisseyWilliam A Coetzee
Jun 30, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Liangzhu YuHuamin Liang
Mar 26, 2004·The Japanese Journal of Physiology·Noritsugu TohseYoichi Yamada
Dec 5, 2013·Journal of Molecular Endocrinology·Eva A Rog-ZielinskaKaren E Chapman
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Viatchenko-KarpinskiJ Hescheler
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·P A DoevendansR S Kass
May 10, 2001·Journal of Molecular and Cellular Cardiology·G N Tseng
Mar 5, 2016·The Review of Scientific Instruments·Katarzyna Anna RadaszkiewiczJiří Pacherník

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