Developmental changes in neural corticosteroid receptor binding capacity in altricial nestlings

Developmental Neurobiology
Haruka Wada, Creagh W Breuner

Abstract

Altricial nestlings typically do not show an adrenocortical response during the early post-hatch period. This may be a result of an immature hypothalamic-pituitary-adrenal axis, or an enhanced control of the axis by negative feedback. To examine whether the dampened adrenocortical response is due to higher receptor densities in hypothalamus and hippocampus, the major sites for negative feedback and tonic inhibition, we explored the ontogenetic changes in glucocorticoid (GR) and mineralocorticoid receptor (MR) binding capacities in the brain of white-crowned sparrow nestlings. During the 10-day nestling period, MR binding capacity decreased with age, whereas GR capacity was not affected. In addition, this overall decline in MR levels was driven entirely by a decline in cerebellar MR. No age-related changes were observed in hippocampal or hypothalamic areas. Our findings suggest that enhanced negative feedback does not play a major role in the attenuated adrenocortical responses seen in white-crowned sparrow nestlings.

References

Jan 1, 1988·Progress in Brain Research·P M Rodier
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R M SapolskyB S McEwen
Dec 17, 1998·Psychoneuroendocrinology·D M Vázquez
Feb 19, 1999·Neurotoxicology and Teratology·S A Ferguson, R R Holson
Aug 11, 2000·General and Comparative Endocrinology·C G Sims, R L Holberton
Oct 24, 2000·General and Comparative Endocrinology·C W BreunerM Orchinik
Aug 6, 2002·General and Comparative Endocrinology·Karen Ann Glennemeier, Robert John Denver
Jun 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C W BreunerJ C Wingfield
Sep 18, 2003·Hormones and Behavior·K A SpencerC K Catchpole
Jan 16, 2004·General and Comparative Endocrinology·Lisa S Hayward, John C Wingfield
Oct 12, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Nicola SainoAnders Pape Møller
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Takeshi KanagawaYuji Murata
Feb 22, 2007·The Journal of Comparative Neurology·Maria ChristenssonMartin Garwicz
May 6, 2008·The Journal of Experimental Biology·Haruka Wada, Creagh W Breuner
Feb 25, 2009·General and Comparative Endocrinology·Creagh W Breuner, Miles Orchinik
May 12, 2009·Physiological and Biochemical Zoology : PBZ·Haruka WadaCreagh W Breuner
Sep 8, 2009·Environmental Science & Technology·Haruka WadaWilliam A Hopkins

❮ Previous
Next ❯

Citations

Jul 22, 2011·Proceedings. Biological Sciences·Sunayana B BanerjeeElizabeth Adkins-Regan
Oct 16, 2015·Biological Reviews of the Cambridge Philosophical Society·Zulima Tablado, Lukas Jenni
Aug 29, 2012·General and Comparative Endocrinology·Christine R LattinL Michael Romero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.