PMID: 16636305Apr 26, 2006Paper

Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction

Experimental Biology and Medicine
James S BarryWilliam W Hay

Abstract

Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction (IUGR) were the focus of our study. Our objective was to test the hypothesis that the fetal ovine myocardium adapts during an IUGR gestation by increasing glucose transporter protein expression, plasma membrane-bound glucose transporter protein concentrations, and insulin signal transduction protein concentrations. Growth measurements and whole heart tissue were obtained at 55 days gestational age (dGA), 90 dGA, and 135 dGA (term = 145 dGA) in fetuses from control (C) and hyperthermic (HT) pregnant sheep. Additionally, in 135 dGA animals, arterial blood was obtained and Doppler ultrasound was used to determine umbilical artery systolic (S) and diastolic (D) flow velocity waveform profiles to calculate pulsatility (S - D/mean) and resistance (S - D/S) indices. Myocardial Glut-1, Glut-4, insulin signal transduction proteins involved in Glut-4 translocation, and glycogen content were measured. Compared to age-matched controls, HT 90-dGA fetal body weights and HT 135-dGA fetal weights and gross heart weights were lower. Heart weights as a percent of body weights were similar betwe...Continue Reading

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Citations

Feb 5, 2009·American Journal of Physiology. Endocrinology and Metabolism·Sean W LimesandWilliam W Hay
Jun 26, 2010·Experimental Biology and Medicine·Timothy R H RegnaultFrederick C Battaglia
May 12, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leticia E CamachoSean W Limesand
Jul 18, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexander L PendletonSean W Limesand
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Sep 27, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sean W LimesandWilliam W Hay
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Aug 16, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ramkumar MohanEmilyn Uy Alejandro
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