Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: relevance to epileptiform bursting susceptibility

Neuroscience
Benjamin J Whalley, A Constanti

Abstract

Suppression of depolarizing postsynaptic potentials and isolated GABA-A receptor-mediated fast inhibitory postsynaptic potentials by the muscarinic acetylcholine receptor agonist, oxotremorine-M (10 microM), was investigated in adult and immature (P14-P30) rat piriform cortical (PC) slices using intracellular recording. Depolarizing postsynaptic potentials evoked by layers II-III stimulation underwent concentration-dependent inhibition in oxotremorine-M that was most likely presynaptic and M2 muscarinic acetylcholine receptor-mediated in immature, but M1-mediated in adult (P40-P80) slices; percentage inhibition was smaller in immature than in adult piriform cortex. In contrast, compared with adults, layer Ia-evoked depolarizing postsynaptic potentials in immature piriform cortex slices in oxotremorine-M, showed a prolonged multiphasic depolarization with superimposed fast transients and spikes, and an increased 'all-or-nothing' character. Isolated N-methyl-d-aspartate receptor-mediated layer Ia depolarizing postsynaptic potentials (although significantly larger in immature slices) were however, unaffected by oxotremorine-M, but blocked by dl-2-amino-5-phosphonovaleric acid. Fast inhibitory postsynaptic potentials evoked by laye...Continue Reading

References

Mar 19, 1976·Brain Research·M S Berry, V W Pentreath
May 27, 1991·Neuroscience Letters·G J Stuart, S J Redman
Sep 1, 1990·Developmental Biology·J Holliday, N C Spitzer
May 1, 1988·Neuroscience·F P EckensteinJ Quinn
May 20, 1983·The Journal of Comparative Neurology·M B Luskin, J L Price
Jun 1, 1993·Trends in Neurosciences·M E Hasselmo, J M Bower
Jul 16, 1993·Brain Research. Developmental Brain Research·C M Milburn, D A Prince
Jul 5, 1996·Mechanisms of Ageing and Development·T ArakiY Itoyama
Dec 1, 1996·Progress in Neurobiology·W Löscher, U Ebert
Aug 1, 1997·Molecular Neurobiology·E Barkai, M H Hasselmo
Oct 9, 1999·Epilepsy Research·R M Gardiner
Dec 10, 1999·Neuroscience Letters·P ChabaudR Gervais
May 2, 2001·The Journal of Comparative Neurology·J J EkstrandL B Haberly
Jun 8, 2001·Reviews in the Neurosciences·E Barkai, D Saar
Jul 11, 2002·Brain Research·Amy C PorterChristian C Felder
Jan 7, 2004·Brain Research·Soizic Potier, Caterina Psarropoulou
Mar 4, 2005·Journal of Neurophysiology·Vander Baptista, Wamberto Antonio Varanda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.